CHI3L1 Antibodies

AND CHI3L1 ELISA kits, CHI3L1 Proteins

Many biological assays use antibodies to detect CHI3L1, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with CHI3L1 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop CHI3L1 antibodies...

We validate the specificity of these antibodies to CHI3L1 by testing them on tissues known to express CHI3L1 positively and negatively. Browse below to find the CHI3L1 antibody that suites your experiment. We have 11 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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CHI3L1 Infographic by Boster Bio

All CHI3L1 Products

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Product

Figures

Specificity

Applications

Price

Human Chitinase 3-like 1/YKL-40 ELISA Kit PicoKine®

2 Citations 9 Q&As

Human

ELISA

$499
Cat # EK0974
96 wells/kit, with removable strips.

Mouse Chitinase 3-like 1/YKL-40 ELISA Kit PicoKine®

2 Citations 7 Q&As

Mouse

ELISA

$499
Cat # EK0975
96 wells/kit, with removable strips.

Anti-CHI3L1 Antibody Picoband®

7 Q&As

Mouse

ELISA, WB

$370
Cat # A01283-1
100 μg/vial

Anti-Chitinase-3-like protein 1 CHI3L1 Antibody

Human, Mouse, Rat

$405
Cat # A01283
100ul

Anti-Chitinase-3-like protein 1 CHI3L1 Antibody

Human

IHC, WB

$380
Cat # A01283-2
100ul

Human Chitinase 3-like Recombinant Protein

SDS-PAGE

$281
Cat # PROTP36222
Starting from 10ug

Mouse Chitinase 3-Like 1/YKL-40 PicoKine® Quick ELISA Kit

Mouse

ELISA

$499
Cat # FEK0975
96 wells/kit, with removable strips.

Human Chitinase 3-Like 1/YKL-40 PicoKine® Quick ELISA Kit

Human

ELISA

$499
Cat # FEK0974
96 wells/kit, with removable strips.

Anti-YKL-40/CHI3L1 Antibody Picoband®

Human, Mouse, Rat

ELISA, IF, ICC, WB

$370
Cat # A01283-3
100 μg/vial

CHI3L1 (NM_001276) Human Over-expression Lysate

Human

$628
Cat # LS001116
100 µg

Human recombinant CHI3L1 (Chitinase-3-like protein 1) protein, AF

Human

Cell Culture

$77
Cat # PROTP36222-4
5ug,20ug,100ug

CHI3L1 Overview

Facts about Chitinase-3-like protein 1.

CHI3L1 3D structure. Source: alphafold

Chitinase-3-like protein 1 (CHI3L1)

Carbohydrate-binding lectin with a taste for chitin. Has no chitinase activity.

May play a role in tissue remodeling and in the capacity of cells to react to and cope with changes in their surroundings. Plays a role in T-helper cell type 2 (Th2) inflammatory response and IL-13-induced inflammation, regulating allergen sensitization, inflammatory cell apoptosis, dendritic cell accumulation and M2 macrophage differentiation.

Gene Information

Human
Gene Name:	CHI3L1
Uniprot:	P36222
Entrez:	1116

Family

Belongs to:

glycosyl hydrolase 18 family

Alternative Names

AW208766; Brp39; CHI3L1; Chitinase 3 like 1; Chitinase 3-like 1; gp39; HCgp39; YKL-40

Molecular Weight

Mass (kDA):
42.625 kDA

Genomic Context


Human

Location:	1q32.1
Sequence:	1; NC_000001.11 (203178931..203186704, complement)

Tissue Specificity

Present in activated macrophages, articular chondrocytes, synovial cells as well as in liver. Very low or undetectable expression in non-inflammatory colon. Undetectable in muscle tissues, lung, pancreas, mononuclear cells, or fibroblasts.

Subcellular Localizations

Secreted, extracellular space. Cytoplasm. Cytoplasm, perinuclear region. Endoplasmic reticulum.

Diseases

Inflammation
Malignant Neoplasms
Neoplasms
Arthritis
Rheumatoid Arthritis
Degenerative Polyarthritis
Fibrosis
Asthma
Glioblastoma
Malignant Paraganglionic Neoplasm
Diabetes Mellitus
Brain Neoplasms
Carcinoma

Glioma
Malignant Neoplasm Of Breast
Liver Cirrhosis
Diabetes Mellitus, Non-insulin-dependent
Tumor Angiogenesis
Neoplasm Metastasis
Hepatitis

Interacting Proteins

IL13RA2
LGALS3

Pathways

Tissue Remodeling
Pathogenesis
Secretion
Angiogenesis
Cell Proliferation
Immune Response
Localization
Cell Migration
Cell Cycle
Cell Death
Macrophage Activation
Aging

Innate Immune Response
Inflammatory Response
Cell Adhesion
Cell Differentiation
Excretion
Hypersensitivity
Chemotaxis

PTMs

Phosphorylation
Methylation
Carboxylation
Glycosylation

Cleavage
Deacetylation
Citrullination
Oxidation

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/CHI3L1

References

PMID: 8245017 by Hakala B.E., et al. Human cartilage gp-39, a major secretory product of articular chondrocytes and synovial cells, is a mammalian member of a chitinase protein family.

PMID: 9244440 by Rehli M., et al. Molecular characterization of the gene for human cartilage gp-39 (CHI3L1), a member of the chitinase protein family and marker for late stages of macrophage differentiation.

4 Publications of Boster CHI3L1 Antibodies & ELISA Kits

PubMed ID: 10.1186/s13024-017-0226-4, YKL-40 in the brain and cerebrospinal fluid of neurodegenerative dementias
PubMed ID: 10.1097/MD.0000000000014920, Serum YKL-40 predicts long-term outcome in patients undergoing primary percutane...
PubMed ID: 10.1038/s41434-020-00202-0, Adenovirus vector-mediated YKL-40 shRNA attenuates eosinophil airway inflammatio...
PubMed ID: 10.1016/j.ajg.2021.03.002, Comparison between galectin-3 and YKL-40 levels for the assessment of liver fibr...

*More publications can be found for each product on its corresponding product page