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- Table of Contents
Facts about Chromodomain-helicase-DNA-binding protein 2.
Involved in myogenesis via interaction with MYOD1: binds to myogenic gene regulatory sequences and mediates incorporation of histone H3.3 prior to the beginning of myogenic gene expression, promoting their expression (By similarity).
Human | |
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Gene Name: | CHD2 |
Uniprot: | O14647 |
Entrez: | 1106 |
Belongs to: |
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SNF2/RAD54 helicase family |
ATP-dependent helicase CHD2; CHD-2; chromodomain helicase DNA binding protein 2; chromodomain-helicase-DNA-binding protein 2; DKFZp547I1315; DKFZp686E01200; DKFZp781D1727; EC 3.6.1; EC 3.6.4.12; FLJ38614
Mass (kDA):
211.344 kDA
Human | |
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Location: | 15q26.1 |
Sequence: | 15; NC_000015.10 (92900324..93027996) |
Nucleus. Binds to myogenic gene promoters.
PMID: 9326634 by Woodage T., et al. Characterization of the CHD family of proteins.
PMID: 23708187 by Carvill G.L., et al. Targeted resequencing in epileptic encephalopathies identifies de novo mutations in CHD2 and SYNGAP1.