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Centromere protein F Antibodies
AND CENPF ELISA kits, Centromere protein F Proteins
Many biological assays use antibodies to detect Centromere protein F, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Centromere protein F in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Centromere protein F antibodies...
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CENPF Infographic by Boster Bio
All CENPF Products
Product
Figures
Specificity
Applications
Price
Human
ELISA, Flow Cytometry, IF, ICC, WB
$370
Cat # A03311-1
100 μg/vial
Cat # A03311-1
100 μg/vial
CENPF Overview
Facts about Centromere protein F.
Centromere protein F (CENPF)
Required for kinetochore function and chromosome segregation in mitosis. Required for kinetochore localization of dynein, LIS1, NDE1 and NDEL1.
Regulates recycling of the plasma membrane by acting as a link between recycling vesicles along with the microtubule network though its association with STX4 and SNAP25. Acts as a potential inhibitor of pocket protein-mediated cellular processes during development by regulating the activity of RB proteins during cell division and proliferation.
Gene Information
| Human | |
|---|---|
| Gene Name: | CENPF |
| Uniprot: | P49454 |
| Entrez: | 1063 |
Family
| Belongs to: |
|---|
| centromere protein F family |
Alternative Names
AH antigen; cell-cycle-dependent 350K nuclear protein; CENF; CENP-F kinetochore protein; CENP-F; centromere protein F (350/400kD, mitosin); centromere protein F; centromere protein F, 350/400ka (mitosin); centromere protein F, 350/400kDa (mitosin); hcp-1; Kinetochore protein CENPF; mitosin; PRO1779
Molecular Weight
Mass (kDA):
357.527 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 1q41 |
| Sequence: | 1; NC_000001.11 (214603195..214664571) |
Subcellular Localizations
Cytoplasm, perinuclear region. Nucleus matrix. Chromosome, centromere, kinetochore. Cytoplasm, cytoskeleton, spindle. Relocalizes to the kinetochore/centromere (coronal surface of the outer plate) and the spindle during mitosis. Observed in nucleus during interphase but not in the nucleolus. At metaphase becomes localized to areas including kinetochore and mitotic apparatus as well as cytoplasm. By telophase, is concentrated within the intracellular bridge at either side of the mid-body.
Diseases
- Malignant Neoplasms
- Neoplasms
- Carcinoma
- Adenocarcinoma
- Cell Invasion
- Malignant Neoplasm Of Breast
- Mammary Neoplasms
- Esophageal Neoplasms
- Liver Carcinoma
- Squamous Cell Carcinoma Of Esophagus
- Carcinogenesis
- Nervousness
Interacting Proteins
- NDEL1
- NUP133
Pathways
- Chromosome Segregation
- Cell Division
- System Development
- Cell Cycle
- Nervous System Development
- Pathogenesis
- Cell Adhesion
- Transport
- Immune Response
- Centromere Binding
- Membrane Depolarization
- Reverse Transcription
- Translation
PTMs
- Phosphorylation
Research Areas
- Cancer
- Cell Cycle and Replication
- Chromatin Research
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/CENPF
bosterbio.com/bosterbio-gene-info-cards/CENPF
References
PMID: 7542657 by Liao H., et al. CENP-F is a protein of the nuclear matrix that assembles onto kinetochores at late G2 and is rapidly degraded after mitosis.
PMID: 7651420 by Zhu X., et al. Characterization of a novel 350-kilodalton nuclear phosphoprotein that is specifically involved in mitotic-phase progression.