CECR2 Antibodies

AND CECR2 ELISA kits, CECR2 Proteins

Many biological assays use antibodies to detect CECR2, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with CECR2 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop CECR2 antibodies...

We validate the specificity of these antibodies to CECR2 by testing them on tissues known to express CECR2 positively and negatively. Browse below to find the CECR2 antibody that suites your experiment. We have 0 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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CECR2 Infographic by Boster Bio

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CECR2 Overview

Facts about Cat eye syndrome critical region protein 2.

CECR2 3D structure. Source: alphafold

Cat eye syndrome critical region protein 2 (CECR2)

Chromatin reader part of histone-modifying complexes, like the CERF (CECR2-containing-remodeling factor) complex and ISWI-type complicated (PubMed:15640247, PubMed:26365797, PubMed:22464331). It thereby plays a role in a variety of processes during development: required during embryogenesis for neural tube closure and inner ear development.

In adults, required for spermatogenesis, through the formation of ISWI-type chromatin complexes (By similarity). In histone-modifying complexes, CECR2 recognizes and binds acylated histones: binds histones which are acetylated and/or butyrylated (PubMed:26365797, PubMed:22464331).

Gene Information

Human
Gene Name:	CECR2
Uniprot:	Q9BXF3
Entrez:	27443

Family

Belongs to:

No superfamily

Alternative Names

cat eye syndrome chromosome region, candidate 2; KIAA1740

Molecular Weight

Mass (kDA):
164.213 kDA

Genomic Context


Human

Location:	22q11.1-q11.21
Sequence:	22; NC_000022.11 (17359949..17558155)

Tissue Specificity

Highly expressed in skeletal muscle, thymus, placenta and lung. Expressed at lower level in brain, heart, colon, spleen, kidney.

Diseases

Exencephaly
Cat Eye Syndrome
Aneuploidy
Extra Unidentified Structurally Abnormal Chromosome (disorder)
Anencephaly
Malnutrition
Congenital Ocular Coloboma (disorder)
Atresia
Congenital Cerebral Hernia
Myeloid Leukemia
Neoplasms
Nervousness

Memory Impairment
Cleft Face
Cytogenetic Abnormality
Anus, Imperforate
Congenital Abnormality
Chromosomal Duplication
Male Infertility

Pathways

Chromatin Remodeling
Neural Tube Closure
Tube Closure
Inner Ear Development
Spermatogenesis
Ear Development
Interphase
Transport
Atp-dependent Chromatin Remodeling
Nucleosome Positioning
Neurogenesis

Metaphase
Embryo Development
Cytokinesis
Nuclear Transport
Long-term Memory

PTMs

Acetylation

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/CECR2

References

PMID: 11381032 by Footz T.K., et al. Analysis of the cat eye syndrome critical region in humans and the region of conserved synteny in mice: a search for candidate genes at or near the human chromosome 22 pericentromere.

PMID: 11827465 by Liu L., et al. Sequence analysis of LRPPRC and its SEC1 domain interaction partners suggests roles in cytoskeletal organization, vesicular trafficking, nucleocytosolic shuttling, and chromosome activity.