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CEACAM6 Antibodies
AND CEACAM6 ELISA kits, CEACAM6 Proteins
Many biological assays use antibodies to detect CEACAM6, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with CEACAM6 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop CEACAM6 antibodies...
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CEACAM6 Infographic by Boster Bio
All CEACAM6 Products
Product
Figures
Specificity
Applications
Price
Human, Mouse, Rat
IP, IF, IHC, ICC, WB
$370
Cat # M03197-1
100 μl
Cat # M03197-1
100 μl
CEACAM6 Overview
Facts about Carcinoembryonic antigen-related cell adhesion molecule 6.
Carcinoembryonic antigen-related cell adhesion molecule 6 (CEACAM6)
Cell surface glycoprotein that plays a role in cell adhesion and tumor development (PubMed:2803308, PubMed:2022629, PubMed:1378450, PubMed:8776764, PubMed:11590190, PubMed:10910050, PubMed:14724575, PubMed:16204051). Intercellular adhesion occurs in a calcium- and fibronectin-independent manner (PubMed:2022629, PubMed:16204051).
Heterophilic interaction with CEACAM8 occurs in activated neutrophils (PubMed:8776764). Plays a role in neutrophil adhesion to cytokine-activated endothelial cells (PubMed:1378450).
Gene Information
| Human | |
|---|---|
| Gene Name: | CEACAM6 |
| Uniprot: | P40199 |
| Entrez: | 4680 |
Family
| Belongs to: |
|---|
| immunoglobulin superfamily |
Alternative Names
carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific crossreacting antigen); carcinoembryonic antigen-related cell adhesion molecule 6; CD66c antigen; CD66c; CEACAM6; CEACAM-6; CEAL; NCA; NCACEAL; Non-specific crossreacting antigen; Normal cross-reacting antigen
Molecular Weight
Mass (kDA):
37.195 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 19q13.2 |
| Sequence: | 19; NC_000019.10 (41755529..41772211) |
Tissue Specificity
Expressed in neutrophils (PubMed:1378450). Expressed in columnar epithelial and goblet cells of the colon (PubMed:10436421). Expressed in numerous tumor cell lines (at protein level) (PubMed:16204051).
Subcellular Localizations
Cell membrane; Lipid-anchor, GPI-anchor. Apical cell membrane. Cell surface. Localized to the apical glycocalyx surface.
Diseases
- Tissue Adhesions
- Malignant Neoplasms
- Neoplasms
- Adenocarcinoma
- Carcinoma
- Neoplasm Metastasis
- Pancreatic Neoplasm
- Leukemia
- Crohn Disease
- Pancreatic Adenocarcinoma
- Malignant Neoplasm Of Pancreas
- Cell Transformation, Neoplastic
- Cell Invasion
Interacting Proteins
- CARTPT
- CEACAM1
- RHOXF2
- UBQLN2
- ZMYND19
Pathways
- Cell Adhesion
- Pathogenesis
- Anoikis
- Phagocytosis
- Gene Silencing
- Cell Proliferation
- Localization
- Neutrophil Activation
- Cell Growth
- Angiogenesis
- Rna Interference
- Immune Response
- Virulence
PTMs
- Phosphorylation
- Cleavage
Research Areas
- Cancer
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/CEACAM6
bosterbio.com/bosterbio-gene-info-cards/CEACAM6
References
PMID: 3220478 by Barnett T., et al. Carcinoembryonic antigen family: characterization of cDNAs coding for NCA and CEA and suggestion of nonrandom sequence variation in their conserved loop-domains.
PMID: 3337731 by Tawaragi Y., et al. Primary structure of nonspecific crossreacting antigen (NCA), a member of carcinoembryonic antigen (CEA) gene family, deduced from cDNA sequence.