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CDKN2C Antibodies
AND CDKN2C ELISA kits, CDKN2C Proteins
Many biological assays use antibodies to detect CDKN2C, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with CDKN2C in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop CDKN2C antibodies...
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CDKN2C Infographic by Boster Bio
All CDKN2C Products
Product
Figures
Specificity
Applications
Price
Human, Mouse, Rat
WB
$523
Cat # M03299
100 µl
Cat # M03299
100 µl
Human, Mouse, Rat
IP, IF, IHC, ICC, WB
$370
Cat # M03299-1
100 μl/vial
Cat # M03299-1
100 μl/vial
CDKN2C Overview
Facts about Cyclin-dependent kinase 4 inhibitor C.
Cyclin-dependent kinase 4 inhibitor C (CDKN2C)
Interacts strongly with CDK6, weakly with CDK4.
Inhibits cell growth and proliferation with a correlated dependence on endogenous retinoblastoma protein RB..
Gene Information
| Human | |
|---|---|
| Gene Name: | CDKN2C |
| Uniprot: | P42773 |
| Entrez: | 1031 |
Family
| Belongs to: |
|---|
| CDKN2 cyclin-dependent kinase inhibitor family |
Alternative Names
CDK6 inhibitor p18; CDKN2C; CDKN6; cyclin-dependent inhibitor; cyclin-dependent kinase 4 inhibitor C; Cyclin-dependent kinase 6 inhibitor; cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4); INK4Ccyclin-dependent kinase 6 inhibitor p18; p18; p18INK4c; p18-INK4C; p18-INK6
Molecular Weight
Mass (kDA):
18.127 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 1p32.3 |
| Sequence: | 1; NC_000001.11 (50968695..50974634) |
Tissue Specificity
Highest levels found in skeletal muscle. Also found in pancreas and heart.
Diseases
- Neoplasms
- Malignant Neoplasms
- Retinoblastoma
- Cell Transformation, Neoplastic
- Leukemia
- Carcinoma
- Pituitary Diseases
- Lymphoma
- Hyperplasia
- Malignant Paraganglionic Neoplasm
- Pituitary Neoplasms
- Myeloid Leukemia
- Brain Neoplasms
Interacting Proteins
- AHCYL1
- CDK4
- CDK6
- NAGK
- NIF3L1
- REL
- TCF12
- TCF4
Pathways
- Cell Cycle
- Cell Proliferation
- Pathogenesis
- Cell Growth
- Cell Cycle Arrest
- Cell Division
- Methylation
- Cell Differentiation
- Cell Death
- G1 Phase
- Oncogenesis
- Dna Replication
- S Phase
PTMs
- Phosphorylation
Research Areas
- Cell Cycle and Replication
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/CDKN2C
bosterbio.com/bosterbio-gene-info-cards/CDKN2C
References
PMID: 8001816 by Guan K.-L., et al. Growth suppression by p18, a p16INK4/MTS1- and p14INK4B/MTS2-related CDK6 inhibitor, correlates with wild-type pRb function.
PMID: 9636670 by Blais A., et al. Structure of the gene encoding the human cyclin-dependent kinase inhibitor p18 and mutational analysis in breast cancer.