CDC7 Antibodies

Cell division cycle 7-related protein kinase (CDC7)

Appears to phosphorylate critical substrates that regulate the G1/S phase transition and/or DNA replication. Can phosphorylates MCM2 and MCM3.

.

Gene Information

Human
Gene Name:	CDC7
Uniprot:	O00311
Entrez:	8317

Family

Belongs to:
protein kinase superfamily

Alternative Names

CDC7 (cell division cycle 7, S. cerevisiae, homolog)-like 1; CDC7 cell division cycle 7 (S. cerevisiae); CDC7L1MGC117361; CDC7-related kinase; cell division cycle 7 (S. cerevisiae); cell division cycle 7 homolog (S. cerevisiae); cell division cycle 7-like protein 1; cell division cycle 7-related protein kinase; EC 2.7.11.1; HsCDC7; Hsk1; huCdc7; MGC126237; MGC126238

Molecular Weight

Mass (kDA):
63.888 kDA

Genomic Context

Human
Location:	1p22.1
Sequence:	1; NC_000001.11 (91498968..91525764)

Subcellular Localizations

Nucleus.

Diseases

• Malignant Neoplasms
• Neoplasms
• Genomic Instability
• Stenosis
• Ataxia
• Carcinoma
• Glaucoma
• Melanoma
• Lymphoma
• Chromosomal Duplication
• Ataxia Telangiectasia
• Malignant Neoplasm Of Breast

• Growth Arrest
• Cell Transformation, Neoplastic
• Sudden Infant Death Syndrome
• Malignant Paraganglionic Neoplasm
• Diffuse Large B-cell Lymphoma
• Neoplasm Metastasis
• Glaucoma, Open-angle

Interacting Proteins

• DBF4
• MCMBP
• ZBTB8B

Pathways

• Dna Replication
• Cell Cycle
• S Phase
• Cell Division
• Mitosis
• Cytokinesis
• Localization
• Meiosis
• Anaphase
• G1 Phase
• Cell Death
• Dna Repair
• Chromosome Segregation

• Cell Proliferation
• Interphase
• Nuclear Division
• Meiosis I
• Mitotic Cell Cycle
• Mating
• Regulation Of Dna Replication

PTMs

• Phosphorylation
• Cleavage
• Dephosphorylation

• Acetylation
• Ubiquitination
• Sumoylation

Research Areas

• Cell Cycle and Replication
• Core ESC-Like Genes
• DNA Repair
• DNA replication, Transcription, Translation and Splicing
• GPCR

• Stem Cell Markers

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/CDC7

Best Uses Of The CDC7 Marker

You've probably heard of the CDC7 Marker. But what is its real function in the body? It has both a tumor suppressive and a promoting role. This article will discuss both of these roles as well as the sources that provide its information. Here's an introduction to this protein. Although CDC7 is present in small amounts in the body, it has important clinical implications.

GSK3ss has the potential to play both tumor suppressive as well as tumor stimulating roles

GSK-3 is a remarkably expressed serine/threonine Kinase, is involved in various signaling pathways and has multiple functions. Its primary function is to regulate glycogen synthesis, but it also serves numerous other functions. In this article, we will look at some of these functions. GSK-3 is implicated in both tumorigenesis as well as autophagy dysregulation, as per molecular models.

Sources

CaCDC7 is a gene Candida albicans suppress. By using a PCR primer, CDC7 can be introduced to an ACT1p58 plasmid p6HF. Then, CaCDC7 M3/ cells are chosen for transformation using the CDC7 T436A primer. CDC7 was also incorporated into the p6HF ACT1p plasmid.

CaCdc7, a conserved gene is composed of two domains of kinase. It is also found in human cells as well as S. cerevisiae. There are three distinct subdomains that are containing the CDC7 gene. Subdomain VI is further divided into subdomains VIa and VIb. The subdomains CaCdc7 and ScCdc7 are closely related, but have distinct functions.