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CDC34 Antibodies
AND CDC34 ELISA kits, CDC34 Proteins
Many biological assays use antibodies to detect CDC34, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with CDC34 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop CDC34 antibodies...
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CDC34 Infographic by Boster Bio
All CDC34 Products
Product
Figures
Specificity
Applications
Price
Human, Mouse, Rat
Flow Cytometry, IP, IF, ICC, WB
$370
Cat # M03038
100 μl
Cat # M03038
100 μl
CDC34 Overview
Facts about Ubiquitin-conjugating enzyme E2 R1.
Ubiquitin-conjugating enzyme E2 R1 (CDC34)
Accepts ubiquitin in the E1 complicated and catalyzes its covalent attachment to other proteins. Cooperates with the E2 UBCH5C and the SCF(FBXW11) E3 ligase complex for the polyubiquitination of NFKBIA leading to its subsequent proteasomal degradation.
Performs ubiquitin chain elongation building ubiquitin chains in the UBE2D3-primed NFKBIA-linked ubiquitin. UBE2D3 acts as an initiator E2, priming the phosphorylated NFKBIA target at positions'Lys-21' or'Lys-22' using a monoubiquitin.
Gene Information
| Human | |
|---|---|
| Gene Name: | CDC34 |
| Uniprot: | P49427 |
| Entrez: | 997 |
Family
| Belongs to: |
|---|
| ubiquitin-conjugating enzyme family |
Alternative Names
Cdc34; cell division cycle 34 homolog (S. cerevisiae); cell division cycle 34; E2-CDC34; EC 6.3.2.19; UBC3; UBE2R1; UBE2R1UBCH3; ubiquitin carrier protein; ubiquitin-conjugating enzyme E2 R1; Ubiquitin-conjugating enzyme E2-32 kDa complementing; Ubiquitin-conjugating enzyme E2-CDC34; Ubiquitin-protein ligase R1
Molecular Weight
Mass (kDA):
26.737 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 19p13.3 |
| Sequence: | 19; NC_000019.10 (531720..542088) |
Tissue Specificity
Expressed in testes during spermatogenesis to regulate repression of cAMP-induced transcription.
Subcellular Localizations
Cytoplasm. Nucleus. The phosphorylation of the C-terminal tail plays an important role in mediating nuclear localization. Colocalizes with beta-tubulin on mitotic spindles in anaphase.
Diseases
- Neoplasms
- Malignant Neoplasms
- Von Hippel-lindau Syndrome
- Cell Transformation, Neoplastic
- Adenocarcinoma
- Virus Diseases
- Leukemia
- Carcinoma
- Burkitt Lymphoma
- Malignant Tumor Of Colon
- Hypoxia
- Hepatitis B
Interacting Proteins
- CUL1
- SDCBP
- SIAH1
Pathways
- Cell Cycle
- Conjugation
- Proteolysis
- S Phase
- Cell Division
- Mitosis
- Localization
- Dna Repair
- Dna Replication
- Cell Growth
- Sporulation
- G1 Phase
- Cell Proliferation
PTMs
- Ubiquitination
- Phosphorylation
Research Areas
- Cancer
- Cell Cycle and Replication
- Core ESC-Like Genes
- Stem Cell Markers
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/CDC34
bosterbio.com/bosterbio-gene-info-cards/CDC34
References
PMID: 8248134 by Plon S.E., et al. Cloning of the human homolog of the CDC34 cell cycle gene by complementation in yeast.
PMID: 10329681 by Gonen H., et al. Identification of the ubiquitin carrier proteins, E2s, involved in signal-induced conjugation and subsequent degradation of IkappaBalpha.