Macrosialin Antibodies

AND CD68 ELISA kits, Macrosialin Proteins

Many biological assays use antibodies to detect Macrosialin, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Macrosialin in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Macrosialin antibodies...

We validate the specificity of these antibodies to Macrosialin by testing them on tissues known to express CD68 positively and negatively. Browse below to find the CD68 antibody that suites your experiment. We have 9 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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CD68 Video by Boster Bio

All CD68 Products

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Product

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Specificity

Applications

Price

Anti-Macrosialin CD68 Antibody Picoband®

56 Citations 9 Q&As

Mouse, Rat

Flow Cytometry, IF, IHC, WB

$370
Cat # PA1518
100 μg/vial

Anti-Macrosialin CD68 Antibody Picoband®

32 Citations 16 Q&As

Human

IHC, WB

$370
Cat # PA2018
100 μg/vial

Anti-CD68 (Macrophage Marker) Monoclonal Antibody

16 Citations 15 Q&As

Human, Monkey, Rabbit, Cat

Flow Cytometry, IF, IHC

$486
Cat # M00602
100ug/vial

Anti-CD68/Sr D1 Rabbit Monoclonal Antibody

18 Citations 4 Q&As

Human, Mouse, Rat

$370
Cat # M00602-1
100 μl

Anti-Human CD68 Monoclonal Antibody, Flow Validated

4 Citations

Human

Flow Cytometry

$147
Cat # FC00602
100ug, 500ug

Anti-Macrosialin CD68 Monoclonal Antibody

20 Citations

Human, Mouse, Rat

IF, IHC-P

$380
Cat # M00602-2
100ul

Human CD68 Recombinant Protein

1 Citations

SDS-PAGE

$250
Cat # PROTP34810
Starting from 10ug

Anti-CD68 Antibody

Human

ELISA, IF, IHC

$370
Cat # A00602-1
100 μg/vial

CD68 (NM_001251) Human Over-expression Lysate

Human

$628
Cat # LS000968
100 µg

CD68 Overview

Facts about Macrosialin.

CD68 3D structure. Source: alphafold

Macrosialin (CD68)

Could play a role in phagocytic activities of tissue macrophages, both in intracellular lysosomal metabolism and extracellular cell-cell and cell-pathogen interactions. Binds to tissue- and organ-specific lectins or selectins, allowing homing of macrophage subsets to specific sites.

Rapid recirculation of CD68 from endosomes and lysosomes to the plasma membrane may allow macrophages to creep over selectin-bearing substrates or other tissues. .

Gene Information

Human
Gene Name:	CD68
Uniprot:	P34810
Entrez:	968

Family

Belongs to:

LAMP family

Alternative Names

CD68 antigenmacrophage antigen CD68; CD68 molecule; CD68; DKFZp686M18236; gp110; Macrosialin; SCARD1; scavenger receptor class D, member 1; SRD1; SR-D1

Molecular Weight

Mass (kDA):
37.408 kDA

Genomic Context


Human

Location:	17p13.1
Sequence:	17; NC_000017.11 (7579638..7582111)

Tissue Specificity

Highly expressed by blood monocytes and tissue macrophages. Also expressed in lymphocytes, fibroblasts and endothelial cells. Expressed in many tumor cell lines which could allow them to attach to selectins on vascular endothelium, facilitating their dissemination to secondary sites.

Subcellular Localizations

[Isoform Short]: Cell membrane; Single-pass type I membrane protein.; [Isoform Long]: Endosome membrane; Single-pass type I membrane protein. Lysosome membrane; Single-pass type I membrane protein.

Diseases

Neoplasms
Inflammation
Malignant Neoplasms
Carcinoma
Malignant Paraganglionic Neoplasm
Fibrosis
Sarcoma
Neoplasm Metastasis
Lymphoma
Tissue Adhesions
Skin Neoplasms
Atherosclerosis
Hyperplasia

Histiocytosis
Pathologic Neovascularization
Arthritis
Leukemia
Dental Plaque
Rheumatoid Arthritis
Histiocytoma, Benign Fibrous

Interacting Proteins

TOMM6

Pathways

Pathogenesis
Immune Response
Angiogenesis
Localization
Cell Proliferation
Inflammatory Response
Secretion
Phagocytosis
Cell Adhesion
Cell Death
Regeneration
Wound Healing
Cytokine Production

Macrophage Activation
Cell Differentiation
Cell Activation
Cell Growth
Macrophage Differentiation
Cell Cycle
Bone Resorption

PTMs

Phosphorylation
Cleavage
Acetylation
Glycosylation
Nitration
Oxidation
Biotinylation

Ubiquitination
Methylation
Carboxylation
Carbamylation
Citrullination
Iodination
Deglycosylation

Research Areas

Cell Biology
Cytokine Research
Immunology

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/CD68

References

PMID: 7680921 by Holness C.L., et al. Molecular cloning of CD68, a human macrophage marker related to lysosomal glycoproteins.

PMID: 9790779 by Jones E., et al. The linked human elongation initiation factor 4A1 (EIF4A1) and CD68 genes map to chromosome 17p13.

74 Publications of Boster Macrosialin Antibodies & ELISA Kits

PubMed ID: 10.3390/ijms20082014, Targeting Brain Disease in MPSII: Preclinical Evaluation of IDS-Loaded PLGA Nano...
PubMed ID: 10.3389/fphar.2018.00618, UPLC/Q-TOFMS-Based Metabolomics Approach to Reveal the Protective Role of Other ...
PubMed ID: 10.1158/1535-7163.MCT-15-0995,
HPMA–Copolymer Nanocarrier Targets Tumor-Associated Macrophages in...
PubMed ID: 10.1007/s40618-015-0287-6, 1,25(OH) 2 D 3 downregulates the Toll-like receptor 4-mediated inflammatory path...
PubMed ID: 31327655, Su W, Han HH, Wang Y, Zhang B, Zhou B, Cheng Y, Rumandla A, Gurrapu S, Chakrabor...
PubMed ID: 28854169,
A somatic mutation in erythro-myeloid progenitors causes neurodegene...
PubMed ID: 34020949,
Myeloid-derived growth factor inhibits inflammation and alleviates en...
PubMed ID: -,
Protective effects of Longhu Rendan on chronic liver injury and fibr...
PubMed ID: 33933157,
Combined topical and systemic administration with human adipose-deri...
PubMed ID: 32964311, Paschalidi P,Gkouveris I,Soundia A,Kalfarentzos E,Vardas E, Georgaki M,Kostakis ...
PubMed ID: -,
Tauroursodeoxycholic Acid Alleviates Secondary Injury in Spinal Cord...
PubMed ID: 33841657,
Schistosoma japonicum-derived peptide SJMHE1 promotes peripheral nerv...
PubMed ID: 33771482, Gao Y,Xu Y,Zhao S,Qian L,Song T,Zheng J,Zhang J,Chen B. Growth differentiation f...
PubMed ID: 33708630, Shi D,Wu J,Wu Y,Lin X,Xu C,Lian X. High-Fat Diet-Related Obesity Promotes Uretha...
PubMed ID: 33708630,
High-Fat Diet-Related Obesity Promotes Urethane-Induced Lung Tumorige...
PubMed ID: 32460188,
Tetramethylpyrazine attenuates endotoxin-induced retinal inflammatio...
PubMed ID: -, Yanmin Cui,Yang Lin,Xianjun Meng,Jingxuan Ma,Haotian Deng,Xia Liu,Xinyuan He,Jin...
PubMed ID: -, Jian Pang,Li Zhou,Liqiu Liao et al.Correlation of sTILs Infiltration and UBR5 Ex...
PubMed ID: -, Masahiro Shindo,Masatomo Maeda,Ko Myat et al.LDH-A Knockdown: Changes in The LDH...
PubMed ID: -, Fan Guo,Wei na Kong,Gang Zhao et al.The Correlation Between Tumor-associated Mac...
PubMed ID: -, Wang,Xiaoyu & Wang,Linlin & Qi,Lili & Bian,Huimiao & Yan,Xing & Wang,Yan & Li,Xi...

*Showing only the more recent 20. More publications can be found for each product on its corresponding product page