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CD302 antigen Antibodies
AND CD302 ELISA kits, CD302 antigen Proteins
Many biological assays use antibodies to detect CD302 antigen, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with CD302 antigen in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop CD302 antigen antibodies...
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CD302 Overview
Facts about CD302 antigen.
CD302 antigen (CD302)
Potential multifunctional C-type lectin receptor that may play roles in endocytosis and phagocytosis as well as in cell adhesion and migration. .
Gene Information
| Human | |
|---|---|
| Gene Name: | CD302 |
| Uniprot: | Q8IX05 |
| Entrez: | 9936 |
Family
| Belongs to: |
|---|
| No superfamily |
Alternative Names
BIMLEC; CD302 antigenC-type lectin domain family 13, member A; CD302 molecule; CD302; CLEC13A; CLEC13AMGC22301; C-type lectin domain family 13 member A; DCL1; DCL-1; DCL1C-type lectin BIMLEC; KIAA0022FLJ43091; Type I transmembrane C-type lectin receptor DCL-1
Molecular Weight
Mass (kDA):
26.183 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 2q24.2 |
| Sequence: | 2; NC_000002.12 (159768628..159798255, complement) |
Tissue Specificity
Expressed at moderate levels in monocytes, myeloid blood dendritic cells and granulocytes and at low levels in plasmacytoid blood dendritic cells, monocyte-derived ma crophages and monocyte-derived dendritic cells, with no expression detected in T-lymphocytes, B-lymphocytes and natural killer cells (at protein level). Expressed widely in different tissues, with highest expression levels in liver, lung, peripheral blood leukocytes and spleen, and lowest levels in neuronal tissues, skeletal muscle and ovary. Isoform 2 and isoform 3 are expressed in malignant Hodgkin lymphoma cells called Hodgkin and Reed- Sternberg (HRS) cells.
Subcellular Localizations
Membrane; Single-pass type I membrane protein. Cell projection, filopodium. Cytoplasm, cell cortex. Cell projection, microvillus. Colocalizes with F-actin in filopodia, cellular cortex and microvilli of the apical cell surface.
Diseases
- Neoplasm Metastasis
- Embryonal Carcinoma
- Primary Neoplasm
- Tumor Progression
- Gastrointestinal Neoplasms
- Malignant Paraganglionic Neoplasm
- Neoplasms, Unknown Primary
- Tissue Adhesions
- Diabetes Mellitus
- Hodgkin Disease
- Carcinoma
Pathways
- Cell Adhesion
- Leukocyte Activation
- Cell Differentiation
- Endocytosis
- Localization
- Rna Interference
PTMs
- Disulfide bond
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/CD302
bosterbio.com/bosterbio-gene-info-cards/CD302
References
PMID: 12824192 by Kato M., et al. Hodgkin's lymphoma cell lines express a fusion protein encoded by intergenically spliced mRNA for the multilectin receptor DEC-205 (CD205) and a novel C-type lectin receptor DCL-1.
PMID: 17947679 by Kato M., et al. The novel endocytic and phagocytic C-Type lectin receptor DCL-1/CD302 on macrophages is colocalized with F-actin, suggesting a role in cell adhesion and migration.