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CD244 Antibodies
AND CD244 ELISA kits, CD244 Proteins
Many biological assays use antibodies to detect CD244, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with CD244 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop CD244 antibodies...
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CD244 Infographic by Boster Bio
All CD244 Products
Product
Figures
Specificity
Applications
Price
Human
ELISA
$499
Cat # EK0926
96 wells/kit, with removable strips.
Cat # EK0926
96 wells/kit, with removable strips.
CD244 Overview
Facts about Natural killer cell receptor 2B4.
Natural killer cell receptor 2B4 (CD244)
Heterophilic receptor of the signaling lymphocytic activation molecule (SLAM) family; its ligand is CD48. SLAM receptors triggered by homo- or heterotypic cell-cell interactions are modulating the activation and differentiation of a wide variety of immune cells and are involved in the regulation and interconnection of both innate and adaptive immune response.
Tasks are controlled by presence or absence of small cytoplasmic adapter proteins, SH2D1A/SAP and/or SH2D1B/EAT-2. Downstreaming signaling involves predominantly VAV1, and, to a lesser degree, INPP5D/SHIP1 and CBL.
Gene Information
| Human | |
|---|---|
| Gene Name: | CD244 |
| Uniprot: | Q9BZW8 |
| Entrez: | 51744 |
Family
| Belongs to: |
|---|
| No superfamily |
Alternative Names
2B4; CD244 antigen; CD244 molecule, natural killer cell receptor 2B4; CD244; h2B4; NAIL; NAILNK cell activation-inducing ligand; natural killer cell receptor 2B4; NKR2B4; NKR2B4NK cell type I receptor protein 2B4,2B4CD244 natural killer cell receptor 2B4; Nmrk; SLAMF4; SLAMF4NK cell activation inducing ligand NAIL
Molecular Weight
Mass (kDA):
41.616 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 1q23.3 |
| Sequence: | 1; NC_000001.11 (160830160..160862892, complement) |
Tissue Specificity
Expressed in spleen, PBL, followed by lung, liver, testis and small intestine. Expressed in all natural killer (NK) cells, monocytes and basophils, TCR-gamma/delta+ T-cells, monocytes, basophils, and on a subset of CD8(+) T-cells.
Subcellular Localizations
Membrane; Single-pass type I membrane protein. Cell membrane. Receptor engagement results in a recruitment to lipid drafts essential for the subsequent tyrosine phosphorylation of the ITSMs.
Diseases
- Neoplasms
- X-linked Lymphoproliferative Disorders
- Lymphoproliferative Disorders
- Infective Disorder
- Virus Diseases
- Tissue Adhesions
- Immunologic Deficiency Syndromes
- Malignant Neoplasms
- Epstein-barr Virus Infections
- Autoimmune Reaction
- Leukemia
- Hiv Infections
- Arthritis
Interacting Proteins
- B2M
- CD48
- INPP5D
- PLCG1
- PTPN11
- PTPN6
- SH2D1A
- SH2D1B
Pathways
- Cell Activation
- Lymphocyte Activation
- Secretion
- Cytokine Production
- Immune Response
- Pathogenesis
- Cytolysis
- Cell Differentiation
- Cytokine Secretion
- T Cell Activation
- Cell Proliferation
- Cell Recognition
- Cell Development
PTMs
- Phosphorylation
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/CD244
bosterbio.com/bosterbio-gene-info-cards/CD244
References
PMID: 10359122 by Nakajima H., et al. Activating interactions in human NK cell recognition: the role of 2B4-CD48.
PMID: 10556801 by Kubin M.Z., et al. Molecular cloning and biological characterization of NK cell activation-inducing ligand, a counterstructure for CD48.