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- Table of Contents
Facts about C-C chemokine receptor type 6.
Although CCL20 is its major ligand it may also function as a receptor for non-chemokine ligands for example beta-defensins (PubMed:25585877). Binds to defensin DEFB1 resulting in increase in intracellular calcium ions and cAMP levels.
Human | |
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Gene Name: | CCR6 |
Uniprot: | P51684 |
Entrez: | 1235 |
Belongs to: |
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G-protein coupled receptor 1 family |
BN-1; CC-CKR-6; CCR6; CCR-6; CD196 antigen; CD196; chemokine (C-C motif) receptor 6; CKRL3; CKR-L3; CKR-L3G-protein coupled receptor 29; CKRL3LARC receptor; CMKBR6; CMKBR6STRL22; DRY6; GPR29; GPR29C-C CKR-6; GPRCY4; GPR-CY4; GPRCY4DRY-6; lymphocyte, 22; STRL22
Mass (kDA):
42.494 kDA
Human | |
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Location: | 6q27 |
Sequence: | 6; NC_000006.12 (167111807..167139141) |
Sperm. Mainly localized in the tail and in the postacrosomal region but is also found in the midpiece and basal region in a small percentage of sperm cells. Reduced levels found in the sperms of asthenozoospermia and leukocytospermia patients (at protein level). Spleen, lymph nodes, appendix, and fetal liver. Expressed in lymphocytes, T-cells and B-cells but not in natural killer cells, monocytes or granulocytes.
Cell membrane; Multi-pass membrane protein. Cell surface.
PMID: 9169459 by Baba M., et al. Identification of CCR6, the specific receptor for a novel lymphocyte- directed CC chemokine LARC.
PMID: 8886020 by Zaballos A., et al. Molecular cloning and RNA expression of two new human chemokine receptor-like genes.