Cyclin-T1 Antibodies

AND CCNT1 ELISA kits, Cyclin-T1 Proteins

Many biological assays use antibodies to detect Cyclin-T1, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Cyclin-T1 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Cyclin-T1 antibodies...

We validate the specificity of these antibodies to Cyclin-T1 by testing them on tissues known to express CCNT1 positively and negatively. Browse below to find the CCNT1 antibody that suites your experiment. We have 3 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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CCNT1 Infographic by Boster Bio

All CCNT1 Products

Filter by Application:

Product

Figures

Specificity

Applications

Price

Anti-Cyclin T1/CCNT1 Antibody Picoband®

4 Q&As

Human, Mouse, Rat

Flow Cytometry, IF, IHC, IHC-F, ICC, WB

$370
Cat # PB9990
100 μg/vial

Anti-Cyclin-T1 CCNT1 Antibody

Human, Mouse, Rat

ELISA, IF, IHC-P, WB

$449
Cat # A02703
0.1 mg

Anti-Cyclin T1 Antibody Picoband® (monoclonal, 3B7)

Human, Monkey

Flow Cytometry, WB

$370
Cat # M02703
100 μg/vial

CCNT1 Overview

Facts about Cyclin-T1.

CCNT1 3D structure. Source: alphafold

Cyclin-T1 (CCNT1)

Regulatory subunit of the cyclin-dependent kinase pair (CDK9/cyclin-T1) complex, also called positive transcription elongation factor B (P-TEFb), which is suggested to facilitate the transition from abortive to productive elongation by phosphorylating the CTD (carboxy-terminal domain) of the large subunit of RNA polymerase II (RNA Pol II). .

Gene Information

Human
Gene Name:	CCNT1
Uniprot:	O60563
Entrez:	904

Family

Belongs to:

cyclin family

Alternative Names

CCNT; CCNT1; CCNTcyclin-T; CDK9-associated C-type protein; cyclin C-related protein; cyclin T1; cyclin T1b; Cyclin-T; cyclin-T1; CYCT1; HIVE1; human immunodeficiency virus type 1 (HIV-1) expression (elevated) 1; Human immunodeficiency virus-1 expression; subunit of positive elongation transcription factor b

Molecular Weight

Mass (kDA):
80.685 kDA

Genomic Context


Human

Location:	12q13.11-q13.12
Sequence:	12; NC_000012.12 (48688458..48716707, complement)

Tissue Specificity

Ubiquitously expressed.

Subcellular Localizations

Nucleus.

Diseases

Hiv Infections
Immunologic Deficiency Syndromes
Acquired Immunodeficiency Syndrome
Hypertrophy
Cardiac Hypertrophy
Cytomegalovirus Infections
Anemia
Equine Infectious Anemia
Cell Transformation, Neoplastic
Malignant Neoplasms
Neoplasms

Chimera Disorder
Mammary Neoplasms
Vesicular Stomatitis
Stomatitis
Virus Diseases
Heart Failure

Interacting Proteins

AFF4
CDK9
HEXIM1

Pathways

Viral Replication
Localization
Pathogenesis
Cell Cycle
Viral Transcription
Macrophage Differentiation
Cell Growth
Proteolysis
Reverse Transcription
Nuclear Import
Monocyte Differentiation
Chromatin Remodeling
Hyperphosphorylation

Immune Response
Rna Interference
Virion Assembly
Cell Activation
Cell Division
Cell Differentiation
Cell Proliferation

PTMs

Phosphorylation
Acetylation
Deacetylation

Dephosphorylation
Methylation
Ubiquitination

Research Areas

Cell Cycle and Replication

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/CCNT1

References

PMID: 9491887 by Wei P., et al. A novel CDK9-associated C-type cyclin interacts directly with HIV-1 Tat and mediates its high-affinity, loop-specific binding to TAR RNA.

PMID: 9499409 by Peng J.-M., et al. Identification of multiple cyclin subunits of human P-TEFb.