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G1/S-specific cyclin-D3 Antibodies
AND CCND3 ELISA kits, G1/S-specific cyclin-D3 Proteins
Many biological assays use antibodies to detect G1/S-specific cyclin-D3, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with G1/S-specific cyclin-D3 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop G1/S-specific cyclin-D3 antibodies...
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CCND3 Infographic by Boster Bio
All CCND3 Products
Product
Figures
Specificity
Applications
Price
Anti-Cyclin D3/CCND3 Antibody Picoband®
1 Citations 7 Q&As
Human, Rat
WB
$370
Cat # PB9103
100 μg/vial
Cat # PB9103
100 μg/vial
Human, Mouse
Flow Cytometry, IF, ICC, WB
$370
Cat # M01744
100 μl
Cat # M01744
100 μl
Human, Mouse, Rat
ELISA
$480
Cat # EKC1155
1 kit, containing one 96-well plate and all necessary reagents
Cat # EKC1155
1 kit, containing one 96-well plate and all necessary reagents
Human, Mouse, Rat
ELISA
$540
Cat # EKC2025
1 kit, containing two 96-well plates and all necessary reagents
Cat # EKC2025
1 kit, containing two 96-well plates and all necessary reagents
Human, Mouse, Rat
ELISA, IHC, WB
$380
Cat # A01744T283
100ul
Cat # A01744T283
100ul
CCND3 Overview
Facts about G1/S-specific cyclin-D3.
G1/S-specific cyclin-D3 (CCND3)
Regulatory component of the cyclin D3-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family including RB1 and modulates the cell-cycle during G(1)/S transition. Phosphorylation of RB1 allows dissociation of the transcription factor E2F in the RB/E2F complicated and the subsequent transcription of E2F target genes which are responsible for the progression through the G(1) phase.
Hypophosphorylates RB1 in early G(1) phase. Cyclin D-CDK4 complexes are important integrators of various mitogenenic and antimitogenic signals.
Gene Information
| Human | |
|---|---|
| Gene Name: | CCND3 |
| Uniprot: | P30281 |
| Entrez: | 896 |
Family
| Belongs to: |
|---|
| cyclin family |
Alternative Names
CCND3; Cyclin D3; D3-type cyclin; G1/S-specific cyclin D3; G1/S-specific cyclin-D3
Molecular Weight
Mass (kDA):
32.52 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 6p21.1 |
| Sequence: | 6; NC_000006.12 (41934933..42048894, complement) |
Subcellular Localizations
Nucleus. Cytoplasm. Membrane. Cyclin D-CDK4 complexes accumulate at the nuclear membrane and are then translocated to the nucleus through interaction with KIP/CIP family members.
Diseases
- Neoplasms
- Malignant Neoplasms
- Retinoblastoma
- Lymphoma
- Carcinoma
- Leukemia
- Cell Transformation, Neoplastic
- Mammary Neoplasms
- Malignant Paraganglionic Neoplasm
- Malignant Neoplasm Of Breast
- Growth Arrest
- Chromosomal Translocation
- B-cell Lymphomas
Interacting Proteins
- CDK14
- CDK4
- CDK5
- CDK6
- CDKN1A
- POLR3GL
- TFIP11
Pathways
- Cell Cycle
- Cell Proliferation
- G1 Phase
- S Phase
- Cell Cycle Arrest
- Cell Growth
- Pathogenesis
- Localization
- Cell Division
- Cell Death
- Cell Differentiation
- Translation
- Induction Of Apoptosis
PTMs
- Phosphorylation
- Dephosphorylation
- Cleavage
- Methylation
Research Areas
- Cancer
- Cell Cycle and Replication
- Wnt Signaling Pathway
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/CCND3
bosterbio.com/bosterbio-gene-info-cards/CCND3
References
PMID: 1386336 by Xiong Y., et al. Molecular cloning and chromosomal mapping of CCND genes encoding human D-type cyclins.
PMID: 1383201 by Motokura T., et al. Cloning and characterization of human cyclin D3, a cDNA closely related in sequence to the PRAD1/cyclin D1 proto-oncogene.
1 Publications of Boster G1/S-specific cyclin-D3 Antibodies & ELISA Kits
- PubMed ID: 10.1007/s10616-018-0235-3, Co-culture with TM4 cells enhances the proliferation and migration of rat adipos...
*More publications can be found for each product on its corresponding product page