CCKBR Antibodies

AND CCKBR ELISA kits, CCKBR Proteins

Many biological assays use antibodies to detect CCKBR, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with CCKBR in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop CCKBR antibodies...

We validate the specificity of these antibodies to CCKBR by testing them on tissues known to express CCKBR positively and negatively. Browse below to find the CCKBR antibody that suites your experiment. We have 3 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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CCKBR Infographic by Boster Bio

All CCKBR Products

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Product

Figures

Specificity

Applications

Price

Anti-CCKBR Antibody Picoband®

1 Citations

Human, Mouse, Rat

Flow Cytometry, IHC, ICC, WB

$370
Cat # A01677-1
100 μg/vial

Anti-Human CCKBR DyLight® 488 conjugated Antibody

Human

Flow Cytometry

$515
Cat # A01677-Dyl488
100 μg/vial

Anti-Human CCKBR DyLight® 550 conjugated Antibody

4 Q&As

Human

Flow Cytometry

$515
Cat # A01677-Dyl550
100 μg/vial

CCKBR Overview

Facts about Gastrin/cholecystokinin type B receptor.

CCKBR 3D structure. Source: alphafold

Gastrin/cholecystokinin type B receptor (CCKBR)

Receptor for gastrin and cholecystokinin. The CCK-B receptors occur throughout the central nervous system where they modulate anxiety, analgesia, arousal, and neuroleptic activity.

This receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. .

Gene Information

Human
Gene Name:	CCKBR
Uniprot:	P32239
Entrez:	887

Family

Belongs to:

G-protein coupled receptor 1 family

Alternative Names

CCK2 receptor; CCK2R; CCK2-R; CCK-B receptor; CCK-B; CCKBR; CCK-BR; CCKRB; cholecystokinin B receptor; Cholecystokinin-2 receptor; Cholecystokinin-B R; cholecystokinin-B receptor/gastrin receptor; CholecystokininBR; Cholecystokinin-BR; GASR; Gastrin Receptor; gastrin/cholecystokinin type B receptor

Molecular Weight

Mass (kDA):
48.419 kDA

Genomic Context


Human

Location:	11p15.4
Sequence:	11; NC_000011.10 (6259838..6272127)

Tissue Specificity

Isoform 1 is expressed in brain, pancreas, stomach, the colon cancer cell line LoVo and the T-lymphoblastoma Jurkat, but not in heart, placenta, liver, lung, skeletal muscle, kidney or the stomach cancer cell line AGS. Expressed at high levels in the small cell lung cancer cell line NCI-H510, at lower levels in NCI-H345, NCI-H69 and GLC-28 cell lines, not expressed in GLC-19 cell line. Within the stomach, expressed at high levels in the mucosa of the gastric fundus and at low levels in the antrum and duodenum. Isoform 2 is present in pancreatic cancer cells and colorectal cancer cells, but not in normal pancreas or colonic mucosa. Isoform 3 is expressed in brain, pancreas, stomach, the stomach cancer cell line AGS and the colon cancer cell line LoVo.

Subcellular Localizations

Cell membrane; Multi-pass membrane protein.

Diseases

Panic Disorder
Anxiety Disorders
Malignant Neoplasms
Mental Disorders
Nervousness
Schizophrenia
Neoplasms
Panic Attack
Hallucinations
Mood Disorders
Delirium

Adenocarcinoma
Diabetes Mellitus, Non-insulin-dependent
Withdrawal Sign Or Symptom
Alcoholic Liver Diseases
Pancreatic Neoplasm

Interacting Proteins

CCK
NTM
PTPN11

Pathways

Pathogenesis
Localization
Secretion
Cell Growth
Cell Proliferation
Acid Secretion
Insulin Secretion
Immune Response
Regeneration
Gastric Motility

Cytokine Production
Receptor Internalization
Bone Mineralization
Gastric Acid Secretion

PTMs

Phosphorylation

Amidation

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/CCKBR

References

PMID: 1280419 by Pisegna J.R., et al. Molecular cloning of the human brain and gastric cholecystokinin receptor: structure, functional expression and chromosomal localization.

PMID: 7681836 by Lee Y.-M., et al. The human brain cholecystokinin-B/gastrin receptor. Cloning and characterization.

1 Publications of Boster CCKBR Antibodies & ELISA Kits

PubMed ID: 26136952, Changes in FABP1 and gastrin receptor expression in the testes of rats that have...

*More publications can be found for each product on its corresponding product page