Coiled-coil domain-containing protein 22 (CCDC22)

Involved in regulation of NF-kappa-B signaling.

Promotes ubiquitination of I-kappa-B-kinase subunit IKBKB and its subsequent proteasomal degradation resulting in NF-kappa-B activation; the role may involve affiliation with COMMD8 and a CUL1-dependent E3 ubiquitin ligase complex.

May down-regulate NF- kappa-B action via association with COMMD1 and between a CUL2- dependent E3 ubiquitin ligase complex. Regulates the cellular localization of COMM domain-containing proteins, such as COMMD1 and COMMD10 (PubMed:23563313).