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CBX3 Antibodies
AND CBX3 ELISA kits, CBX3 Proteins
Many biological assays use antibodies to detect CBX3, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with CBX3 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop CBX3 antibodies...
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CBX3 Infographic by Boster Bio
All CBX3 Products
Product
Figures
Specificity
Applications
Price
Human, Mouse, Rat
ELISA, Flow Cytometry, IF, IHC, IHC-F, ICC, WB
$370
Cat # A01142
100 μg/vial
Cat # A01142
100 μg/vial
Human, Mouse, Rat
Flow Cytometry, IP, IHC, WB
$370
Cat # M01142-1
100 μl
Cat # M01142-1
100 μl
Human, Mouse, Rat
ELISA
$480
Cat # EKC1281
1 kit, containing one 96-well plate and all necessary reagents
Cat # EKC1281
1 kit, containing one 96-well plate and all necessary reagents
Human, Mouse, Rat
ELISA
$540
Cat # EKC2595
1 kit, containing two 96-well plates and all necessary reagents
Cat # EKC2595
1 kit, containing two 96-well plates and all necessary reagents
Human, Mouse, Rat
IP, IF, IHC, ICC, WB
$405
Cat # A01142-1
100ul
Cat # A01142-1
100ul
Human, Monkey, Mouse, Rat
IP, IHC, ICC, WB
$482
Cat # M01142
100ul
Cat # M01142
100ul
CBX3 Overview
Facts about Chromobox protein homolog 3.
Chromobox protein homolog 3 (CBX3)
Appears to be involved in transcriptional silencing in heterochromatin-like complexes. Recognizes and binds histone H3 tails methylated at 'Lys-9', leading to epigenetic repression.
May contribute to the institution of the heterochromatin with the inner nuclear membrane through its interaction with lamin B receptor (LBR). Involved in the creation of functional kinetochore through interaction with MIS12 complicated proteins.
Gene Information
| Human | |
|---|---|
| Gene Name: | CBX3 |
| Uniprot: | Q13185 |
| Entrez: | 11335 |
Family
| Belongs to: |
|---|
| No superfamily |
Alternative Names
chromobox homolog 3 (Drosophila HP1 gamma); chromobox homolog 3; chromobox protein homolog 3; Drosophila); HECH; Heterochromatin protein 1 homolog gamma; heterochromatin protein HP1 gamma; heterochromatin-like protein 1; HP1 gamma homolog; HP1 gamma; HP1-GAMMA; Modifier 2 protein
Molecular Weight
Mass (kDA):
20.811 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 7p15.2 |
| Sequence: | 7; NC_000007.14 (26201443..26213607) |
Subcellular Localizations
Nucleus. Associates with euchromatin and is largely excluded from constitutive heterochromatin. May be associated with microtubules and mitotic poles during mitosis (Potential).
Diseases
- Carcinoma
- Immunologic Deficiency Syndromes
- Neoplasms
- Malignant Neoplasms
- Cytomegalovirus Infections
- Malignant Paraganglionic Neoplasm
- Ataxia Telangiectasia
- Crest Syndrome
- Telangiectasis
- Acquired Immunodeficiency Syndrome
- Mutation Abnormality
- Intraepithelial Neoplasia
- Embryonal Carcinoma
Interacting Proteins
- ADNP
- ADNP2
- HIST1H3A
- KMT5C
- LAP3
- LBR
- LRIF1
- PRR14
- SUV39H1
- TRIM28
Pathways
- Methylation
- Gene Silencing
- Dna Methylation
- Histone Modification
- Meiosis
- Mitosis
- Localization
- Regulation Of Gene Expression
- Spermatogenesis
- Cell Cycle
- Prophase
- Cell Differentiation
- Interphase
PTMs
- Methylation
- Phosphorylation
Research Areas
- Core ESC-Like Genes
- Stem Cell Markers
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/CBX3
bosterbio.com/bosterbio-gene-info-cards/CBX3
References
PMID: 8663349 by Ye Q., et al. Interaction between an integral protein of the nuclear envelope inner membrane and human chromodomain proteins homologous to Drosophila HP1.
PMID: 10664448 by Koike N., et al. Identification of heterochromatin protein 1 (HP1) as a phosphorylation target by Pim-1 kinase and the effect of phosphorylation on the transcriptional repression function of HP1.