CBX3 Antibodies

Chromobox protein homolog 3 (CBX3)

Appears to be involved in transcriptional silencing in heterochromatin-like complexes. Recognizes and binds histone H3 tails methylated at 'Lys-9', leading to epigenetic repression.

May contribute to the institution of the heterochromatin with the inner nuclear membrane through its interaction with lamin B receptor (LBR). Involved in the creation of functional kinetochore through interaction with MIS12 complicated proteins.

Gene Information

Human
Gene Name:	CBX3
Uniprot:	Q13185
Entrez:	11335

Family

Belongs to:
No superfamily

Alternative Names

chromobox homolog 3 (Drosophila HP1 gamma); chromobox homolog 3; chromobox protein homolog 3; Drosophila); HECH; Heterochromatin protein 1 homolog gamma; heterochromatin protein HP1 gamma; heterochromatin-like protein 1; HP1 gamma homolog; HP1 gamma; HP1-GAMMA; Modifier 2 protein

Molecular Weight

Mass (kDA):
20.811 kDA

Genomic Context

Human
Location:	7p15.2
Sequence:	7; NC_000007.14 (26201443..26213607)

Subcellular Localizations

Nucleus. Associates with euchromatin and is largely excluded from constitutive heterochromatin. May be associated with microtubules and mitotic poles during mitosis (Potential).

Diseases

• Carcinoma
• Immunologic Deficiency Syndromes
• Neoplasms
• Malignant Neoplasms
• Cytomegalovirus Infections
• Malignant Paraganglionic Neoplasm
• Ataxia Telangiectasia
• Crest Syndrome
• Telangiectasis
• Acquired Immunodeficiency Syndrome
• Mutation Abnormality
• Intraepithelial Neoplasia
• Embryonal Carcinoma

• Malignant Neoplasm Of Breast
• Ataxia
• Seminoma
• Premature Aging Syndrome
• Muscular Dystrophy, Facioscapulohumeral
• Infertility
• X-linked Combined Immunodeficiency Diseases

Interacting Proteins

• ADNP
• ADNP2
• HIST1H3A
• KMT5C
• LAP3

• LBR
• LRIF1
• PRR14
• SUV39H1
• TRIM28

• ZNF280C

Pathways

• Methylation
• Gene Silencing
• Dna Methylation
• Histone Modification
• Meiosis
• Mitosis
• Localization
• Regulation Of Gene Expression
• Spermatogenesis
• Cell Cycle
• Prophase
• Cell Differentiation
• Interphase

• Histone Methylation
• Chromatin Remodeling
• Rna Interference
• Heterochromatin Organization
• Cell Migration
• Stem Cell Differentiation
• Cellular Senescence

PTMs

• Methylation
• Phosphorylation

• Acetylation
• Reduction

• Ubiquitination

Research Areas

• Core ESC-Like Genes
• Stem Cell Markers

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/CBX3

Boster Bio Antibodies - Best Uses Of The CBX3 Marker

Are you interested in the Anti-Caveolin-1 and Anti-GAPDH marker available from Boster Bio? This article will discuss the two markers and give an overview of their functions. If you're in search of a high-quality antibody for use in your research, then you're in the right place. Boster Bio has a wide array of antibodies to pick from, and all of their products are tested on a variety of platforms, and their products have been validated using known positive and negative samples. If you're a scientist, you might be wondering what is the difference between these antibodies and CBX3.

Anti-Caveolin-1/CAV1

Caveolin-1 protein is found in a variety of tissues and plays a significant role in cholesterol and fat transport, cell adhesion, signal transduction and signal transduction. Serum levels are significantly elevated in prostate cancer patients and benign prostatic hypertrophy patients, and their levels correlate with progression of prostate cancer. Caveolin-1 is present in both erosive and non-erosive cells, and its expression is twice as high in cancerous as well as non-erosive tissues. It is also believed to play a role in cell proliferation and differentiation as well as to be a novel therapeutic target.

Caveolin-1 overexpression is linked to an improved prognosis of prostate cancer. It may represent a new risk factor for the disease. Previous studies on the expression of caveolin-1 and prostate cancer yielded inconsistent results due to small sample sizes and ethnic variations. To establish the caveolin-1-prostate-cancer relationship, researchers performed a meta-analysis. They found that caveolin-1 expression is associated with the TNM stage of the tumor, and with lymph node metastasis.

Anti-GAPDH

The multifunctional glycolytic enzyme GAPDH is essential to the survival and resistance of cells against cell death. GAPDH's expression is controlled by several transcription factors, including insulin promoter and hypoxia response components. In addition to its role in cell expansion, GAPDH also plays important roles in the regulation of intracellular membrane trafficking, repair of DNA, and receptor mediated cell signalling. GAPDH is a suitable target for treatment of cancer.

The function of the gene is transcription elongation, alternative Splicing, and DNA damage response. Recent research has linked the gene to cancer. Anti-GAPDH drugs as well as RNA-based immunoassays showed associations between CBX3 and cancers like breast cancer, lung cancer, osteosarcoma and colorectal cancer. It is however not clear how this protein can affect the progression or development of cancer.

TRIzol was used to extract RNA from osteosarcoma osteosarcoma cells and tissue to detect CBX3 gene expression. Takara Bio, Inc., an Japanese biotechnology company, performed qPCR using the One Step RT-PCR Kit. The protocol comprised 40 amplifying cycles. CBX3 primers were purchased from Shanghai Genechem Co., Ltd., while GAPDH was employed as an internal reference.

GAPDH, a key regulator for glycolysis, is found to be overexpressed in 21 kinds of cancer. It also plays a crucial function in the metabolism of tumors and has been linked with colorectal cancer. It has also been proven to be associated with the progression in the cancer in the same way as GAPDH in other kinds of cancers. This marker can be used to detect GAPDH.

Anti-GAPDH is an anti-inflammatory drug that is used for treating diabetes and other metabolic disorders. Its primary components are both phenylalanine and glucose. Both of them are utilized by the body to create insulin. However they differ from other. Other pharmacological effects associated with the CBX3 marker are weight loss and hypertension.

The study included 62 patients with primary CRC. GAPDH expression was not affected by gender or age. Table 1 summarizes the demographic, clinical, as well as tumor-related characteristics for the patients. After a period of 49-months 26 patients died. This marker is still being used in cancer diagnosis. More studies and research are needed. These are not the first steps in order to know the potential of this marker.

The role of CBX3 in the cancer cell cycle is not fully recognized. However, it is clear that it is a significant predictor of outcomes related to cancer. Additionally, it is associated with the size of the tumor as well as distant metastasis. It is also used as a prognostic marker. This marker could be used to identify early indications of osteosarcoma.

The protein is part of the heterochromatin family, and has been linked to a variety of diseases. The methylation process of H3K9 is believed to be the cause of increased levels of CBX3. It is unclear what the underlying mechanism behind the preference for upregulation of CBX3 in carcinogenesis. There is a strong connection between high CBX3 levels, poor survival of patients and cancer, CBX3 plays an important role in the pathological process.

Anti-Caveolin

Caveolins are integral proteins that range from 21 to 24 kDa or larger in size. They interact with cholesterol and lipids and perform a variety of biological roles. Caveolins play an important role in neurodegenerative diseases and interact with a variety of signaling molecules. In immunohistochemistry, caveolins are identified by the presence of a band that recognizes the alpha and beta forms of caveolin proteins.

Caveolin-1 is a 22 kDa membrane protein that is found in caveolae invaginations within plasma membranes. Caveolin-1 plays a crucial role in cell signaling and migration. Recent research has revealed that CBX3 has anti-Caveolin activities within tumors, making it an beneficial tool in studies of tumour development.

Caveolin-1 is expressed in different kinds of tissues, with the highest levels in mesotheliomas and adipocytes. This protein can aid in identifying epithelioid mesotheliomas from lung adeno. Caveolin-1 can also be used to detect Ewing Sarcoma/PNET. This protein is expressed in 96% of cases.