CBX1 Antibodies

Chromobox protein homolog 1 (CBX1)

Component of heterochromatin.

Recognizes and binds histone H3 tails methylated at 'Lys-9', leading to epigenetic repression.

Interaction with lamin B receptor (LBR) can result in the association of the heterochromatin with the inner nuclear membrane. .

Gene Information

Human
Gene Name:	CBX1
Uniprot:	P83916
Entrez:	10951

Family

Belongs to:
No superfamily

Alternative Names

CBXM31HP1-BETA; chromobox homolog 1 (Drosophila HP1 beta); chromobox homolog 1 (HP1 beta homolog Drosophila ); chromobox homolog 1; chromobox protein homolog 1; Heterochromatin protein 1 homolog beta; heterochromatin protein 1-beta; heterochromatin protein p25 beta; Heterochromatin protein p25; HP1 beta homolog; HP1 beta; HP1Hsbeta; HP1Hs-beta; MOD1; Modifier 1 protein; p25beta

Molecular Weight

Mass (kDA):
21.418 kDA

Genomic Context

Human
Location:	17q21.32
Sequence:	17; NC_000017.11 (48070059..48101478, complement)

Tissue Specificity

Expressed in all adult and embryonic tissues.

Subcellular Localizations

Nucleus. Unassociated with chromosomes during mitosis.

Diseases

• Malignant Neoplasms
• Neoplasms
• Neurofibromatosis 1
• Fracture Of First Cervical Vertebra
• Malignant Neoplasm Of Breast
• Endometrial Neoplasms
• Myeloid Leukemia, Chronic
• Partial Deletion Of Y
• Infertility
• Edema
• Steroid Sulfatase Deficiency Disease
• Mammary Neoplasms

• Lentivirus Infections
• Invasive Malignant Neoplasm
• Cell Invasion
• Leukemogenesis
• Cell Transformation, Neoplastic
• Impacted Tooth

Interacting Proteins

• ADNP
• ADNP2
• EMSY
• HIST1H3A
• NR2F6

• SGO1
• SUV39H1
• ZNF280C

Pathways

• Gene Silencing
• Meiosis
• Localization
• Methylation
• Metaphase
• Fertilization
• Cell Cycle
• Interphase
• Heterochromatin Organization
• Regulation Of Gene Expression
• Chromosome Segregation
• Chromatin Organization
• Chromosome Condensation

• Male Meiosis
• S Phase
• Pachytene
• Nuclear Envelope Reassembly
• Transposition
• Cell Migration
• Cerebral Cortex Development

PTMs

• Methylation

• Phosphorylation

• Cleavage

Research Areas

• Chromatin Research

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/CBX1

Boster Bio - Best Uses Of The CBX1 Marker

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Boster offers high-affinity primary antibodies

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High-affinity primary antibodies are the core ingredients of assays and experiments. The binding ability of antibodies to specific antigens is essential to various immunoassays. Examples of immunoassays include Western Blotting, immunohistochemistry, and histopathology. Other methods include ELISA (enzyme-linked immunosorbent assay) and flow cytometry, which measure the number of specific cell types in a sample.

Steven Boster's history

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Born in Joliet, IL, Steve Boster passed away on Sunday, June 26, 2022, in Madison, WI. He was the son of James and Evelyn Meier Boster. He was an Army veteran and a member of Concordia Hall in Staunton, VA. His children, Crystal and Natosha Peck, and grandchildren, Cory and Jonathan, survive him. The family is complete with many nieces and nephews.

Offers high-affinity primary antibodies

A boster bio CBX1 antibody offers the highest affinity and specificity available in a single kit. Primary antibodies are immunoglobulins made from the host's immune system. These antibodies contain regions known as complementarity-determining regions (CDRs), which are complex topics. In general, scientists make polyclonal primary antibodies by immunizing a host with antigens and extracting their antibodies from the host's eggs or sera.

High-affinity antibodies are necessary for the successful use of primary antibodies. Boster offers primary antibodies that are tested and cited in the literature for decades. Their primary antibodies have undergone rigorous validation in ELISA, immunohistochemistry, and Western Blotting. Boster's CBX1 marker is particularly useful for applications where a specific antigen is of high interest.

Primary antibodies and secondary antibodies are the core components of experiments and assays. Immunoassays depend on the ability of primary antibodies to bind antigens. Popular immunoassays include Western Blotting, immunohistochemistry, and immunofluorescence. A third type of immunoassay is flow cytometry, which measures the number of specific cells.