This website uses cookies to ensure you get the best experience on our website.
- Table of Contents
, No Gclids
CBR1 Antibodies
AND CBR1 ELISA kits, CBR1 Proteins
Many biological assays use antibodies to detect CBR1, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with CBR1 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop CBR1 antibodies...
Previous: BFSP1
Next: CBR3
CBR1 Infographic by Boster Bio
All CBR1 Products
Product
Figures
Specificity
Applications
Price
Human, Mouse, Rat
ELISA, Flow Cytometry, IF, IHC, ICC, WB
$370
Cat # A02825-1
100 μg/vial
Cat # A02825-1
100 μg/vial
Human, Mouse, Rat
IHC, WB
$523
Cat # M02825-1
100 µl
Cat # M02825-1
100 µl
CBR1 Overview
Facts about Carbonyl reductase [NADPH] 1.
Carbonyl reductase [NADPH] 1 (CBR1)
NADPH-dependent reductase with broad substrate specificity. Catalyzes the reduction of a wide variety of carbonyl compounds such as quinones, prostaglandins, menadione, plus various xenobiotics.
Catalyzes the reduction of the antitumor anthracyclines doxorubicin and daunorubicin to the cardiotoxic compounds doxorubicinol and daunorubicinol. Can convert prostaglandin E2 to prostaglandin F2-alpha.
Gene Information
| Human | |
|---|---|
| Gene Name: | CBR1 |
| Uniprot: | P16152 |
| Entrez: | 873 |
Family
| Belongs to: |
|---|
| short-chain dehydrogenases/reductases (SDR) family |
Alternative Names
15-hydroxyprostaglandin dehydrogenase [NADP+]; carbonyl reductase (NADPH) 1; carbonyl reductase (NADPH) 1, EC 1.1.1.18410EC 1.1.1.197,15-hydroxyprostaglandin dehydrogenase; carbonyl reductase [NADPH] 1; carbonyl reductase 1; CBR; CRN; EC 1.1.1.184; EC 1.1.1.189; hCBR1; NADPH-dependent carbonyl reductase 1; Prostaglandin 9-ketoreductase; Prostaglandin-E(2) 9-reductase; SDR21C1; short chain dehydrogenase/reductase family 21C, member 1
Molecular Weight
Mass (kDA):
30.375 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 21q22.12 |
| Sequence: | 21; NC_000021.9 (36070024..36073164) |
Subcellular Localizations
Cytoplasm.
Diseases
- Malignant Neoplasms
- Neoplasms
- Mammary Neoplasms
- Malignant Neoplasm Of Breast
- Cardiotoxicity
- Carcinoma
- Endometrial Polyp
- Down Syndrome
- Cardiomyopathies
- Liver Carcinoma
- Myeloid Leukemia
- Diabetes Mellitus
- Liver Neoplasms
Pathways
- Luteolysis
- Secretion
- Localization
- Drug Resistance
- Pathogenesis
- Mating
- Dna Methylation
- Ovulation
- Oocyte Maturation
- Methylation
- Cell Death
- Transport
- Gene Silencing
PTMs
- Demethylation
- Glutathionylation
- Reduction
Research Areas
- Stem Cell Markers
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/CBR1
bosterbio.com/bosterbio-gene-info-cards/CBR1
References
PMID: 3141401 by Wermuth B., et al. Human carbonyl reductase. Nucleotide sequence analysis of a cDNA and amino acid sequence of the encoded protein.
PMID: 2182121 by Forrest G.L., et al. Induction of a human carbonyl reductase gene located on chromosome 21.