CBR1 Antibodies

Carbonyl reductase [NADPH] 1 (CBR1)

NADPH-dependent reductase with broad substrate specificity. Catalyzes the reduction of a wide variety of carbonyl compounds such as quinones, prostaglandins, menadione, plus various xenobiotics.

Catalyzes the reduction of the antitumor anthracyclines doxorubicin and daunorubicin to the cardiotoxic compounds doxorubicinol and daunorubicinol. Can convert prostaglandin E2 to prostaglandin F2-alpha.

Gene Information

Human
Gene Name:	CBR1
Uniprot:	P16152
Entrez:	873

Family

Belongs to:
short-chain dehydrogenases/reductases (SDR) family

Alternative Names

15-hydroxyprostaglandin dehydrogenase [NADP+]; carbonyl reductase (NADPH) 1; carbonyl reductase (NADPH) 1, EC 1.1.1.18410EC 1.1.1.197,15-hydroxyprostaglandin dehydrogenase; carbonyl reductase [NADPH] 1; carbonyl reductase 1; CBR; CRN; EC 1.1.1.184; EC 1.1.1.189; hCBR1; NADPH-dependent carbonyl reductase 1; Prostaglandin 9-ketoreductase; Prostaglandin-E(2) 9-reductase; SDR21C1; short chain dehydrogenase/reductase family 21C, member 1

Molecular Weight

Mass (kDA):
30.375 kDA

Genomic Context

Human
Location:	21q22.12
Sequence:	21; NC_000021.9 (36070024..36073164)

Subcellular Localizations

Cytoplasm.

Diseases

• Malignant Neoplasms
• Neoplasms
• Mammary Neoplasms
• Malignant Neoplasm Of Breast
• Cardiotoxicity
• Carcinoma
• Endometrial Polyp
• Down Syndrome
• Cardiomyopathies
• Liver Carcinoma
• Myeloid Leukemia
• Diabetes Mellitus
• Liver Neoplasms

• Trisomy
• Leukemia
• Adenocarcinoma
• Mental Disorders
• Leukemia, Myelocytic, Acute
• Obesity
• Neoplasm Metastasis

Pathways

• Luteolysis
• Secretion
• Localization
• Drug Resistance
• Pathogenesis
• Mating
• Dna Methylation
• Ovulation
• Oocyte Maturation
• Methylation
• Cell Death
• Transport
• Gene Silencing

• Fertilization
• Proteolysis
• Immune Response
• Hypersensitivity
• Protein Secretion
• Phospholipid Scrambling
• Regulation Of Oocyte Maturation

PTMs

• Demethylation
• Glutathionylation
• Reduction

• Hydroxylation
• Cleavage
• Methylation

Research Areas

• Stem Cell Markers

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/CBR1

Best Uses Of The CBR1 Marker

For many types studies, high-affinity prima antibodies are essential. SDS-PAGE is a great option for recombinant human CBR1 proteins expressed in E.coli. The protein is stable at 2degC- +8degC for a week, so there's no need for repeated freeze-thail cycles. This makes it an extremely valuable tool for scientists.

Steven Boster

Steve Boster, who was born June 26, 2022, died. He was born Joliet, IL. He was a retail sales manager for many years. He was a U.S. Army vet and a Concordia Hall, Staunton, VA, member. He is survived his two daughters, Natosha Peck and Crystal Boster. 6 Grandchildren and 4 brothers, Jack Boster. Many nieces, nephews, and other relatives survived him.

Steve was a sports fan. He enjoyed watching opposing teams and was passionate about auto racing. He didn't miss a Friday night race at the local circuit. He also attended dirt track racing events during weekends. He spent his free time with his loved ones. He enjoyed hunting and fishing. He had a deep appreciation for the outdoors and loved to hunt, fish and camp.

Primary antibodies with high affinity

Boster Bio produces high quality primary antibodies as well as reagents. The company's ELISA kits and antibodies are made in its own facilities, which ensures a consistently high quality standard. The company also offers a custom antibody production service at discounted rates to non-mammal animals. Moreover, its antibody products are optimized and tested to guarantee high-affinity performance. Boster products can be used with confidence in your research.

Flow cytometry is a highly popular technique for analysis of biological samples, such as cells and particles. Boster Bio supplies high affinity primary antibodies for this purpose, including monoclonal or polyclonal antibodies. Boster antibodies have a strong track record of high citation, which highlights their effectiveness across a wide range. It is important that you choose an antibody with high affinity.

These kits can detect a wide array of hormones, molecules, and other substances. In addition, they can also detect 8-OHdG (DNA damage), inflammatory cytokines, and various other molecules. Boster offers reagents for 96 different test types. This makes them perfect for routine diagnostics. Furthermore, Boster offers a wide range of convenient solutions for PCR and ELISA, including a reagent kit that can detect IL-6, IL-8, EGF, and a number of other cytokines.

In addition to the high affinity of these products, they are not susceptible to a range of variations related to cell-line drift. They also retain peak antigen specificity, which allows for more precise diagnostic tests. You can rest assured that your research will yield top-quality results when you use such antibodies. Boster Bio high-affinity prima antibodies are the best choice. You won't regret it! You won't regret it!

Primary antibodies' function is the most important information. The primary antibodies help your cells recognize antigens. They recognize the haptens. These proteins can be produced only by a limited number of B cells. The antibodies are encoded by the VH- and VL genes in mice. These proteins are selected to recognize specific pathogens and haptens. These antibodies can be used for antibody-based tests.

CBR1 Marker

The candidate for p53-mediated transcription regulation is the CBR1 gene. It can be controlled using a variety transcriptional and/or post-transcriptional variables. CBR1 expression under non-basal condition is controlled by AHR. The p53-mediated repression of CBR1 may result in the emergence of cancer. Many possible uses of CBR1 regulation are still unknown.

By examining the CBR1 genetic gene, genetic surveys can be performed. The Coriell Institute for Medical Research conducted genetic surveys using small DNA human variety panels. CBR1 genes are found in around 30% of all human genomes. The gene's genetic analysis has many applications and allows researchers to study the diversity within human populations. Although the CBR1 gene is still understudied, it is now an effective marker for various cancer research.

Researchers analyzed the levels CBR1 mRNA/protein after stratifying the samples according to ethnic origin. Healthy individuals have the CBR1 gene expressed in their livers and pancreas. The CBR1 gene expression was found to be similar in both white and black donors. However, the sample size used in this study may not have been sufficient to identify the biological mechanisms.

The best way for the CBR1 to be used is to do a comparative analysis between these two species. C. elegans is closely related to the CBR1 gene, making it a useful tool for comparative research. Cbrdpy-10 (Arg92Cys), in the same way, is more easily identifiable than other Cbrdpy-10 variants. This makes it an invaluable tool for reliable isolation and identification of Caenorhabditis briggsae markers.

Previous studies showed that Bacteroidales markers had a correlation with the number E. coli or Enterococci found in ruminant samples. The presence of bird polluting was also correlated with the markers. For example, CBR1 markers are high in birds such as swans or gulls that have been in water bodies. These results are very useful in evaluating catchment management.

Applications

Recent studies have demonstrated that the CBR1 cancer marker can be used to detect tumour cells containing the protein. This marker is expressed within the cytoplasm of cancer-cell cells. Positive cells are defined as those with cytoplasmic staining. Intensity can also be measured in the following ways: 0, weak, moderate, strong. The final immunoreactivity scoring is calculated using an equation. It equals the percentage tumor cells that show moderate, weak, or no staining. This score may be anywhere between 0 and 300.

CBR1 is a key component of radiation sensitivity. Radiation activates the protein. HNSCC cell studies showed that CBR1 toxicity can lead to ROS levels up to 61% higher in some cases, which can cause aberrant DNA repairs and cell death. Accumulated damage can eventually lead to senescence. CBR1 is an important marker for cancer research. It has also been implicated in the survival of tumor cells.

The function of the carbonyl-reductase gene to detoxify oxidative compounds from cellular tissues is its main function. This enzyme can detoxify reactive oxides, highly reactive cholesterols, and lipids formed under stressful conditions. Although this enzyme is important in protecting cells, it is not yet clear what its role is in disease. CBR1 gene has had some applications that have highlighted the potential benefits this bioinformatics instrument. CBR1 expression is beneficial in increasing cell survival during hepatocellular tumour treatment.

A one-page form must be submitted along with the application in order to submit a successful application for marker status. The marker review team will examine all applications together with the applications. A vote will be held at September 16th's meeting of the Indiana Library and Historical Board.

Human carbonyl reductase-1 has many applications, including in tumor progression and oxidative Stress. CBR1 has a critical role in cancer and is also important in detecting DNA damages/repair. It also plays a crucial role in the regulation DNA repair and the distribution cells cycles. Cancer researchers can predict the outcome of their patients by measuring CBR1 expression in tumor cells.