Caspase-5 Antibodies

Caspase-5 (CASP5)

Mediator of programmed cell death (apoptosis). Throughout non-canonical inflammasome activation, cuts CGAS and might play a role in the regulation of antiviral innate immune activation (PubMed:28314590).

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Gene Information

Human
Gene Name:	CASP5
Uniprot:	P51878
Entrez:	838

Family

Belongs to:
peptidase C14A family

Alternative Names

CASP5; CASP-5; caspase 5, apoptosis-related cysteine peptidase; caspase 5, apoptosis-related cysteine protease; Caspase5; Caspase-5; EC 3.4.22; EC 3.4.22.58; ICE(rel)III; ICE(rel)-III; ICEREL-III; ICH3; ICH-3; MGC141966; Protease ICH-3; Protease TY; TY protease

Molecular Weight

Mass (kDA):
49.736 kDA

Genomic Context

Human
Location:	11q22.3
Sequence:	11; NC_000011.10 (104994235..105023902, complement)

Tissue Specificity

Expressed in barely detectable amounts in most tissues except brain, highest levels being found in lung, liver and skeletal muscle.

Diseases

• Malignant Neoplasms
• Neoplasms
• Microsatellite Instability
• Colorectal Cancer
• Mutation, Out-of-frame
• Carcinoma
• Endometrial Polyp
• Hereditary Nonpolyposis Colorectal Cancer
• Cell Transformation, Neoplastic
• Adenocarcinoma
• Malignant Neoplasm Of Lung
• Malignant Neoplasm Of Breast
• Malignant Tumor Of Colon

• Blind Vision
• Colorectal Neoplasms
• Carcinogenesis
• Lung Neoplasms
• Leukemia
• Endometrial Carcinoma
• Cholangiocarcinoma

Pathways

• Mismatch Repair
• Cell Death
• Localization
• Translation
• Protein Folding
• Immune Response
• Pathogenesis
• Chromosome Localization
• Cell Proliferation
• Mastication
• Dna Repair
• Donor Selection
• Mitochondrial Depolarization

• Inflammatory Response
• Methylation
• Innate Immune Response
• Cell Growth
• Angiogenesis
• Segmentation
• Apoptotic Process

PTMs

• Cleavage
• Phosphorylation

• Dephosphorylation
• Methylation

Research Areas

• Apoptosis
• Cancer
• Caspases

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/CASP5

Boster Bio: Best Uses Of The CASP5 Marker

Boster Bio's CASP5 marker is a good option for those who are new to ad targeted. This is a highly efficient ad target molecule due to its low competition. This article will give you tips on optimizing your experiments using this ad molecule.

Boster Bio's Marker CASP5

Researchers can use a boster Bio CASP5 marker when performing experiments on Caspase-5. This antibody reacts well with human CASP5. This antibody is made from whole rabbit serum. It was prepared by immunizing rabbits using a synthetic peptide containing 14 amino acids. The blocking peptide is available for purchase and is designed to inhibit the binding of the antibody to the Caspase-5 protein.

Its high affinity

The CASP5 protein encodes a protein which is involved in leishmania specie secretion. Boster has a wide variety of primary antibodies that are highly-affine, well-cited in the research community, and many others. Their methods are validated in ELISA, immunohistochemistry, and Western Blotting. Boster bio has the best uses for the CASP5 marker.

The L80F mutation dominates the L58F mutation, which may explain the altered consequences of two mutations. The cavity contains a hydrophobic center, which is vital for META1 secretory processes. This structure is crucial for secretion. Furthermore, the growth of double mutants is significantly affected by it. However, this mutation is unlikely to have any effect on secretion.

Its low competition

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Its optimization

The secretion and function of the CASP5 gene is important. The CASP5 gene is a candidate for a secretory function, and it has a hydrophobic cavity. This cavity is essential to its function. If the two mutants are paired together, they may have different effects. For example, the double mutant's growth pattern is altered and it has a lower viability than the parent strain.