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Caspase-3 Antibodies
AND CASP3 ELISA kits, Caspase-3 Proteins
Many biological assays use antibodies to detect Caspase-3, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Caspase-3 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Caspase-3 antibodies...
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CASP3 Infographic by Boster Bio
All CASP3 Products
Product
Figures
Specificity
Applications
Price
Human Caspase 3/CASP3 ELISA Kit PicoKine®
4 Citations 6 Q&As
Human
ELISA
$499
Cat # EK1425
96 wells/kit, with removable strips.
Cat # EK1425
96 wells/kit, with removable strips.
Anti-Caspase-3 (P10)/CASP3 Antibody Picoband®
103 Citations 17 Q&As
Human
IHC, ICC, WB
$370
Cat # PA1302-1
100 μg/vial
Cat # PA1302-1
100 μg/vial
Anti-Caspase 3/CASP3 Antibody Picoband®
116 Citations 4 Q&As
Human, Mouse, Rat
WB
$370
Cat # PA1849
100 μg/vial
Cat # PA1849
100 μg/vial
Anti-Caspase-3(P17)/CASP3 Antibody Picoband®
117 Citations 5 Q&As
Mouse, Rat
IHC, WB
$370
Cat # PA1961-1
100 μg/vial
Cat # PA1961-1
100 μg/vial
Anti-Caspase-3/CASP3 Antibody Picoband®
148 Citations 16 Q&As
Human, Mouse, Rat
IF, IHC, ICC, WB
$370
Cat # PB9188
100 μg/vial
Cat # PB9188
100 μg/vial
Anti-Caspase-3 CASP3 Rabbit Monoclonal Antibody
46 Citations 15 Q&As
Human
Flow Cytometry, IP, IF, IHC, ICC, WB
$370
Cat # M00334-5
100 μl
Cat # M00334-5
100 μl
Anti-pro Caspase 3 CASP3 Rabbit Monoclonal Antibody
32 Citations 16 Q&As
Human, Mouse
Flow Cytometry, IP, IF, IHC, ICC, WB
$370
Cat # M00334
100 μl
Cat # M00334
100 μl
Anti-pro Caspase 3 CASP3 Rabbit Monoclonal Antibody
26 Citations 16 Q&As
Human, Mouse
Flow Cytometry, IP, IF, IHC, ICC, WB
$370
Cat # M00334-1
100 μl
Cat # M00334-1
100 μl
Anti-Caspase-3 p12 CASP3 Rabbit Monoclonal Antibody
56 Citations 15 Q&As
Human, Mouse, Rat
IP, IF, IHC, ICC, WB
$370
Cat # M00334-2
100 μl
Cat # M00334-2
100 μl
Anti-active Caspase-3 CASP3 Rabbit Monoclonal Antibody
18 Citations 5 Q&As
Human
IF, IHC, ICC, WB
$370
Cat # M00334-3
100 μl
Cat # M00334-3
100 μl
Anti-active + pro Caspase 3 CASP3 Rabbit Monoclonal Antibody
58 Citations 16 Q&As
Human, Mouse, Rat
IP, IHC, WB
$370
Cat # M00334-4
100 μl
Cat # M00334-4
100 μl
Anti-Human Caspase-3 DyLight® 488 conjugated CASP3 Antibody
49 Citations 4 Q&As
Human
Flow Cytometry
$515
Cat # A00334-Dyl488
100 μg/vial
Cat # A00334-Dyl488
100 μg/vial
Anti-Human Caspase-3 DyLight® 550 conjugated CASP3 Antibody
12 Citations 14 Q&As
Human
Flow Cytometry
$515
Cat # A00334-Dyl550
100 μg/vial
Cat # A00334-Dyl550
100 μg/vial
Anti-Caspase-3 Antibody Picoband® (monoclonal, 8B6)
16 Citations 16 Q&As
Human
Flow Cytometry, IHC, WB
$370
Cat # M00334-6
100 μg/vial
Cat # M00334-6
100 μg/vial
Anti-Caspase-3 Antibody Picoband® (monoclonal, 15G8)
17 Citations 15 Q&As
Human
Flow Cytometry, IF, IHC, ICC, WB
$370
Cat # M00334-7
100 μg/vial
Cat # M00334-7
100 μg/vial
Anti-Caspase-3 Rabbit Monoclonal Antibody, Clone#RM250
12 Citations 16 Q&As
Human
IHC, WB
$431
Cat # M00334-8
100ul
Cat # M00334-8
100ul
Human, Mouse, Rat
ELISA
$480
Cat # EKC1086
1 kit, containing one 96-well plate and all necessary reagents
Cat # EKC1086
1 kit, containing one 96-well plate and all necessary reagents
Human, Mouse, Rat
ELISA
$540
Cat # EKC2227
1 kit, containing two 96-well plates and all necessary reagents
Cat # EKC2227
1 kit, containing two 96-well plates and all necessary reagents
Human, Mouse, Rat
ELISA, IHC, WB
$380
Cat # A00334S150
100ul
Cat # A00334S150
100ul
Enzyme Activity, SDS-PAGE
$346
Cat # PROTP42574
Starting from 10ug
Cat # PROTP42574
Starting from 10ug
Anti-Caspase-3(p17)/CASP3 Antibody Picoband®
1 Citations
Human
Flow Cytometry, IF, ICC, WB
$370
Cat # A00334-2
100 μg/vial
Cat # A00334-2
100 μg/vial
Human, Mouse, Rat
IP, IHC, WB
$370
Cat # M00334-9
100 μl/vial
Cat # M00334-9
100 μl/vial
Human
ELISA
$499
Cat # FEK1425
96 wells/kit, with removable strips.
Cat # FEK1425
96 wells/kit, with removable strips.
CASP3 Overview
Facts about Caspase-3.
Caspase-3 (CASP3)
Involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) in a'216-Asp-.
Gene Information
| Human | |
|---|---|
| Gene Name: | CASP3 |
| Uniprot: | P42574 |
| Entrez: | 836 |
Family
| Belongs to: |
|---|
| peptidase C14A family |
Alternative Names
Apopain; apoptosis-related cysteine protease; CASP3; CASP-3; caspase 3, apoptosis-related cysteine peptidase; Caspase3; Caspase-3; CPP32; CPP-32; CPP32B; CPP32SREBP cleavage activity 1; Cysteine protease CPP32; EC 3.4.22; EC 3.4.22.56; LICE-1; PARP cleavage protease; procaspase3; Protein Yama; SCA-1; YAMA
Molecular Weight
Mass (kDA):
31.608 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 4q35.1 |
| Sequence: | 4; NC_000004.12 (184627696..184649475, complement) |
Tissue Specificity
Highly expressed in lung, spleen, heart, liver and kidney. Moderate levels in brain and skeletal muscle, and low in testis. Also found in many cell lines, highest expression in cells of the immune system.
Subcellular Localizations
Cytoplasm.
Diseases
- Malignant Neoplasms
- Neoplasms
- Leukemia
- Carcinoma
- Ischemia
- Inflammation
- Nerve Degeneration
- Neuroblastoma
- Liver Carcinoma
- Alzheimer's Disease
- Malignant Paraganglionic Neoplasm
- Malignant Neoplasm Of Breast
- Neurodegenerative Disorders
Interacting Proteins
- AKAP8
- AKT3
- CASP6
- CASP9
- MDM2
- NMT2
- PARP1
- TXN
- WNK3
- XIAP
Pathways
- Cell Death
- Induction Of Apoptosis
- Cell Cycle
- Cell Proliferation
- Programmed Cell Death
- Cell Growth
- Pathogenesis
- Apoptotic Process
- Proteolysis
- Cell Cycle Arrest
- Localization
- Neuroprotection
- Release Of Cytochrome C From Mitochondria
PTMs
- Cleavage
- Phosphorylation
- Dephosphorylation
- Reduction
- Oxidation
- Acetylation
- Ubiquitination
- Methylation
- Nitrosylation
- Biotinylation
Research Areas
- Alzheimers Research
- Apoptosis
- Cancer
- Caspases
- Cell Biology
- Lipid and Metabolism
- Neurodegeneration
- Neuroscience
- Signal Transduction
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/CASP3
bosterbio.com/bosterbio-gene-info-cards/CASP3
References
PMID: 7983002 by Fernandes-Alnemri T., et al. CPP32, a novel human apoptotic protein with homology to Caenorhabditis elegans cell death protein Ced-3 and mammalian interleukin-1 beta-converting enzyme.
PMID: 7774019 by Tewari M., et al. Yama/CPP32 beta, a mammalian homolog of CED-3, is a CrmA-inhibitable protease that cleaves the death substrate poly(ADP-ribose) polymerase.
175 Publications of Boster Caspase-3 Antibodies & ELISA Kits
- PubMed ID: PMID:31933975, MicroRNA-124 represents a novel diagnostic marker in human lupus nephritis and p...
- PubMed ID: PMID:28559975, Inhibition of glioblastoma growth and invasion by 125I brachytherapy in rat glio...
- PubMed ID: PMID:26064215, Effects of PDTC on NF-κB expression and apoptosis in rats with severe acute pan...
- PubMed ID: 10.4103/1673-5374.153698, Ulinastatin suppresses endoplasmic reticulum stress and apoptosis in the hippoca...
- PubMed ID: 10.3969/j.issn.1673-5374.2013.23.009, Antenatal taurine reduces cerebral cell apoptosis in fetal rats with intrauterin...
- PubMed ID: 10.3892/mmr.2017.6160, Inhibitory effects of vitamin E on osteocyte apoptosis and DNA oxidative damage ...
- PubMed ID: 10.3389/fphar.2019.00988, Erxian Decoction Attenuates TNF-α Induced Osteoblast Apoptosis by Modulating th...
- PubMed ID: 10.3389/fmed.2021.732039, Hyperoxia Provokes Time- and Dose-Dependent Gut Injury and Endotoxemia and Alter...
- PubMed ID: 10.3389/fcvm.2021.659643, Pilose Antler Peptide-3.2KD Ameliorates Adriamycin-Induced Myocardial Injury Thr...
- PubMed ID: 10.2147/DDDT.S265198, Integrated Network Pharmacology Analysis and Experimental Validation to Reveal t...
- PubMed ID: 10.1155/2020/3481758, Hydroxy-α-sanshool Possesses Protective Potentials on H2O2-Stimulated PC12 Cell...
- PubMed ID: 10.1142/S0192415X15500299, Apocynum venetum Attenuates Acetaminophen-Induced Liver Injury in Mice
- PubMed ID: 10.1111/os.13019, The Protective Effects of Parathyroid Hormone (1-34) on Cartilage and Subchondra...
- PubMed ID: 10.1039/C7RA13726E, Shunaoxin dropping pill, a Chinese herb compound preparation, attenuates memory ...
- PubMed ID: 10.1016/j.wneu.2018.07.265, Adrenomedullin Reduces Secondary Injury and Improves Outcome in Rats with Fluid ...
- PubMed ID: 10.1016/j.toxicon.2007.07.020, Effect of Huwentoxin-I on the Fas and TNF apoptosis pathway in the hippocampus o...
- PubMed ID: 10.1016/j.physbeh.2015.07.036, The effects of acupuncture and traditional Chinese medicines on apoptosis of bra...
- PubMed ID: 10.1016/j.joen.2020.03.010, Effects of Calcitonin Gene-related Peptide on Dental Pulp Stem Cell Viability, P...
- PubMed ID: 10.1016/j.jep.2008.10.042, Total saponins of Panax Notoginseng modulate the expression of caspases and atte...
- PubMed ID: 10.1016/j.intimp.2016.01.013, Smad2 increases the apoptosis of activated human hepatic stellate cells induced ...
- PubMed ID: 10.1016/j.ijpharm.2016.08.037, Vitamin E TPGS modified liposomes enhance cellular uptake and targeted delivery ...
*Showing only the more recent 20. More publications can be found for each product on its corresponding product page