Caspase-1 Antibodies

AND CASP1 ELISA kits, Caspase-1 Proteins

Many biological assays use antibodies to detect Caspase-1, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Caspase-1 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Caspase-1 antibodies...

We validate the specificity of these antibodies to Caspase-1 by testing them on tissues known to express CASP1 positively and negatively. Browse below to find the CASP1 antibody that suites your experiment. We have 11 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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CASP1 Infographic by Boster Bio

All CASP1 Products

Filter by Application:

Product

Figures

Specificity

Applications

Price

Anti-Caspase-1(P20)/CASP1 Antibody Picoband®

23 Citations 16 Q&As

Human

IHC, WB

$370
Cat # PA1440
100 μg/vial

Anti-Caspase-1(P20)/CASP1 Antibody Picoband®

24 Citations 17 Q&As

Mouse, Rat

$370
Cat # PA1440-1
100 μg/vial

Anti-Caspase-1(P10)/CASP1 Antibody Picoband®

22 Citations 5 Q&As

Human

IHC, WB

$370
Cat # PA1522
100 μg/vial

Anti-Caspase-1 CASP1 Rabbit Monoclonal Antibody

3 Citations 17 Q&As

Human, Rat

IHC, WB

$370
Cat # M00048
100 μl

Caspase 1 Colorimetric Cell-Based ELISA Kit

Human, Mouse, Rat

ELISA

$480
Cat # EKC1083
1 kit, containing one 96-well plate and all necessary reagents

Caspase 1 (Phospho-Ser376) Colorimetric Cell-Based ELISA Kit

Human, Mouse, Rat

ELISA

$540
Cat # EKC2284
1 kit, containing two 96-well plates and all necessary reagents

Anti-Phospho-Caspase-1 (S376) CASP1 Antibody

Human, Mouse, Rat

ELISA, IHC, WB

$380
Cat # A00048S376
100ul

Caspase 1 (CASP1) (NM_033294) Human Recombinant Protein

$1062
Cat # PROTP29466
20 µg

Anti-Caspase-1 + p10 + p12 Rabbit Monoclonal Antibody

Human, Mouse, Rat

IP, WB

$370
Cat # M00048-2
100 μl/vial

Caspase 1 (CASP1) (NM_001223) Human Over-expression Lysate

Human

$628
Cat # LS000834
100 µg

Anti-Caspase 1(p20)/CASP1 Antibody Picoband®

Human

ELISA, WB

$370
Cat # A00048-1
100 µg/vial

CASP1 Overview

Facts about Caspase-1.

CASP1 3D structure. Source: alphafold

Caspase-1 (CASP1)

Thiol protease that cleaves IL-1 beta between an Asp and an Ala, releasing the mature cytokine that is involved in many different inflammatory processes. Important for defense against pathogens.

Cleaves and activates sterol regulatory element binding proteins (SREBPs). Can also promote apoptosis.

Gene Information

Human
Gene Name:	CASP1
Uniprot:	P29466
Entrez:	834

Family

Belongs to:

peptidase C14A family

Alternative Names

CASP1; CASP-1; caspase 1, apoptosis-related cysteine peptidase (interleukin 1, beta; caspase 1, apoptosis-related cysteine protease (interleukin 1, beta; Caspase1; Caspase-1; EC 3.4.22; EC 3.4.22.36; ICE; ICEP45; IL-1 beta-converting enzyme; IL1BC CASP1 nirs variant 1; IL-1BC; IL1BCE; IL1B-convertase; interleukin 1-B converting enzyme; interleukin 1-beta convertase; Interleukin-1 beta convertase; Interleukin-1 beta-converting enzyme; p45

Molecular Weight

Mass (kDA):
45.159 kDA

Genomic Context


Human

Location:	11q22.3
Sequence:	11; NC_000011.10 (105025443..105035591, complement)

Tissue Specificity

Expressed in larger amounts in spleen and lung. Detected in liver, heart, small intestine, colon, thymus, prostate, skeletal muscle, peripheral blood leukocytes, kidney and testis. No expression in the brain.

Subcellular Localizations

Cytoplasm. Cell membrane.

Diseases

Inflammation
Malignant Neoplasms
Neoplasms
Infective Disorder
Cell Transformation, Neoplastic
Carcinoma
Salmonella Infections
Malignant Neoplasm Of Breast
Coronary Artery Disease
Inflammatory Response
Colorectal Cancer
Innate Immune Response
Immunologic Deficiency Syndromes

Infarction
Myocardial Infarction
Tissue Adhesions
Atherosclerosis
Hyperplasia
Colitis
Systemic Infection

Interacting Proteins

CARD17
CARD18
FGF2
IL1A
MEFV

NLRC4
NLRP1
NOD2
PYCARD
VAC14

Pathways

Cell Death
Pathogenesis
Secretion
Immune Response
Localization
Cell Proliferation
Inflammatory Response
Pyroptosis
Cell Cycle
Innate Immune Response
Cell Adhesion
Cell Activation
Dna Methylation

Dna Repair
Methylation
Angiogenesis
Cell Migration
Chemokine Production
Cell Wall Modification
Dna Hypomethylation

PTMs

Cleavage

Phosphorylation

Methylation

Research Areas

Apoptosis
Caspases

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/CASP1

References

PMID: 1574116 by Thornberry N.A., et al. A novel heterodimeric cysteine protease is required for interleukin-1 beta processing in monocytes.

PMID: 1373520 by Cerretti D.P., et al. Molecular cloning of the interleukin-1 beta converting enzyme.

27 Publications of Boster Caspase-1 Antibodies & ELISA Kits

PubMed ID: 10.1016/j.ecoenv.2021.113097, Synergistic effects of botanical curcumin-induced programmed cell death on the m...
PubMed ID: -, Peng Yuan,Xifeng Sun,Xiao Liu,Georg Hutterer,Karl Pummer,Boris Hager,Zhangqun Ye...
PubMed ID: 33681944, Yang L,Liu Y,Wang Y,Li J,Liu N. Azeliragon ameliorates Alzheimer‘s disease...
PubMed ID: 33549657, Zhang XL,Huang WM,Tang PC,Sun Y,Zhang X,Qiu L,Yu BC,Zhang XY,Hong YX,He Y,Ge XQ....
PubMed ID: 32758603, Yang R,Li Y,Mehmood S,Yan C,Huang Y,Cai J,Ji J,Pan W,Zhang W,Chen Y.Polysacchari...
PubMed ID: 32952148, Fan X,Ma W,Zhang Y,Zhang L.P2X7 Receptor (P2X7R) of Microglia Mediates Neuroinfl...
PubMed ID: 21625440, Ding Y, Zou J, Li Z, Tian J, Abdelalim S, Du F, She R, Wang D, Tan C, Wang H, Ch...
PubMed ID: 25813065, Zhang D, Yan H, Hu Y, Zhuang Z, Yu Z, Hang C. J Stroke Cerebrovasc Dis. 2015 May...
PubMed ID: 25761252, Peng K, Liu L, Wei D, Lv Y, Wang G, Xiong W, Wang X, Altaf A, Wang L, He D, Wang...
PubMed ID: 21248471, Zhao Y, Wu S, Wu J, Jia P, Gao S, Yan X, Wang Y. Cancer Biol Ther. 2011 Jan 1;11...
PubMed ID: 25747387, Liu N, Chen T, Wang X, Yang D, Xue B, Zhu H. Febs Lett. 2015 Apr 2;589(8):897-90...
PubMed ID: 22647236, Shu Hf, Yu Sx, Zhang Cq, Liu Sy, Wu Kf, Zang Zl, Yang H, Zhou Sw, Yin Q. Brain D...
PubMed ID: 25780423, Wang Xf, Qu Xq, Zhang Tt, Zhang Jf. Exp Ther Med. 2015 Apr;9(4):1283-1291. Epub ...
PubMed ID: 23073807, Li M, Peng J, Song Y, Liang H, Mei Y, Fang Y. J Huazhong Univ Sci Technolog Med ...
PubMed ID: 25657685, Wu Z, Wang L, Hou S. Neural Regen Res. 2012 Jul 5;7(19):1493-7. Doi: 10.3969/J.I...
PubMed ID: 24935781, Chen A, Dang T, Wang S, Tang N, Liu Y, Wu W. Sci China Life Sci. 2014 Jul;57(7):...
PubMed ID: 25206897, Yuan X, Sun Q, Ou Y, Wang S, Zhang W, Deng H, Wu X, Zhang L. Neural Regen Res. 2...
PubMed ID: 26032740, Chen S, Peng H, Rowat A, Gao F, Zhang Z, Wang P, Zhang W, Wang X, Qu L. Brain Re...
PubMed ID: 24798292, Dai C, Li J, Tang S, Li J, Xiao X. Antimicrob Agents Chemother. 2014 Jul;58(7):4...
PubMed ID: 25661376, Ji J, Yan X, Li Z, Lai Z, Liu J. Biomed Pharmacother. 2015 Feb;69:311-6. Doi: 10...
PubMed ID: 20960169, Lin S, Lin K, Li W, Zhou X, Huang T. Endocrine. 2010 Jun;37(3):460-6. Doi: 10.10...

*Showing only the more recent 20. More publications can be found for each product on its corresponding product page