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CABYR Antibodies
AND CABYR ELISA kits, CABYR Proteins
Many biological assays use antibodies to detect CABYR, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with CABYR in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop CABYR antibodies...
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CABYR Overview
Facts about Calcium-binding tyrosine phosphorylation-regulated protein.
Calcium-binding tyrosine phosphorylation-regulated protein (CABYR)
May function as a regulator of both motility- and mind - associated functions like capacitation and the acrosome reaction. Isoform 1 binds calcium in vitro.
Isoform 2 and isoform 6 likely bind calcium. Isoform 3 and isoform 5 do not bind calcium in vitro.
Gene Information
| Human | |
|---|---|
| Gene Name: | CABYR |
| Uniprot: | O75952 |
| Entrez: | 26256 |
Family
| Belongs to: |
|---|
| No superfamily |
Alternative Names
CABYRa; CABYRc; calcium binding tyrosine-(Y)-phosphorylation regulated; Calcium-binding protein 86; calcium-binding tyrosine-(Y)-phosphorylation regulated (fibrousheathin 2); Cancer/testis antigen 88; CBP86CABYRc/d; CT88MGC9117; fibrousheathin 2; Fibrousheathin II; fibrousheathin-2; FSP-2calcium binding tyrosine-(Y)-phosphorylation regulated (fibrousheathin 2); FSP2calcium-binding tyrosine phosphorylation-regulated protein; Testis-specific calcium-binding protein CBP86
Molecular Weight
Mass (kDA):
52.774 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 18q11.2 |
| Sequence: | 18; NC_000018.10 (24138956..24161600) |
Tissue Specificity
Expressed in elongating spermatids and spermatozoa (at protein level). Isoform 1 is expressed in testis. Isoform 3 and isoform 5 are also expressed in brain, pancreas and numerous brain tumors.
Subcellular Localizations
Cytoplasm, cytoskeleton. Cell projection, cilium, flagellum. Localized to fibrous sheath including the surface of the longitudinal columns and ribs of the principal piece of sperm flagella.; [Isoform 1]: Nucleus. Cytoplasm. Cell projection, cilium, flagellum. According to PubMed:15752768, isoform 1, isoform 3 and isoform 5 are both nuclear and cytoplasmic.; [Isoform 3]: Nucleus. Cytoplasm. Cell projection, cilium, flagellum. According to PubMed:15752768, isoform 1, isoform 3 and isoform 5 are both nuclear and cytoplasmic.; [Isoform 5]: Nucleus. Cytoplasm. Cell projection, cilium, flagellum. Ac
Diseases
- Malignant Neoplasms
- Malignant Neoplasm Of Lung
- Neoplasms
- Brain Neoplasms
- Lung Neoplasms
- Liver Neoplasms
- Autoimmunity
- Liver Carcinoma
- Carcinogenesis
Interacting Proteins
- GSK3B
Pathways
- Localization
- Spermatogenesis
- Cell Proliferation
- Brain Development
- Fertilization
- Immune Response
- Mucus Secretion
- Translation
- Sperm Motility
- Cell Cycle
- Acrosome Reaction
PTMs
- Phosphorylation
Research Areas
- Signal Transduction
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/CABYR
bosterbio.com/bosterbio-gene-info-cards/CABYR
References
PMID: 11820818 by Naaby-Hansen S., et al. CABYR, a novel calcium-binding tyrosine phosphorylation-regulated fibrous sheath protein involved in capacitation.
PMID: 15752768 by Hsu H.-C., et al. Characterization of two non-testis-specific CABYR variants that bind to GSK3beta with a proline-rich extensin-like domain.