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- Table of Contents
Facts about Calcineurin-binding protein cabin-1.
Inhibition of activated calcineurin depends on both PKC and calcium signals. Acts as a negative regulator of p53/TP53 by keeping p53 in an inactive state on chromatin in promoters of a subset of it's target genes.
Human | |
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Gene Name: | CABIN1 |
Uniprot: | Q9Y6J0 |
Entrez: | 23523 |
Belongs to: |
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No superfamily |
calcineurin binding protein 1; Calcineurin inhibitor; calcineurin-binding protein cabin-1; KIAA0330CAINcalcineurin binding protein cabin 1; PPP3IN
Mass (kDA):
246.352 kDA
Human | |
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Location: | 22q11.23 |
Sequence: | 22; NC_000022.11 (24011192..24178628) |
Widely expressed in different tissues.
Nucleus.
PMID: 9655484 by Sun L., et al. Cabin 1, a negative regulator for calcineurin signaling in T lymphocytes.
PMID: 14718166 by Tagami H., et al. Histone H3.1 and H3.3 complexes mediate nucleosome assembly pathways dependent or independent of DNA synthesis.