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- Table of Contents
Facts about Carbonic anhydrase 4.
It is essential for acid overload elimination from the retina and retina epithelium, and acid release from the choriocapillaris in the choroid. .
Human | |
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Gene Name: | CA4 |
Uniprot: | P22748 |
Entrez: | 762 |
Belongs to: |
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alpha-carbonic anhydrase family |
CA4; CAIV; CA-IV; Car4; Carbonate dehydratase IV; carbonic anhydrase 4; Carbonic Anhydrase IV; carbonic anhydrase IVRP17; carbonic dehydratase IV; EC 4.2.1.1; retinitis pigmentosa 17 (autosomal dominant); RP17
Mass (kDA):
35.032 kDA
Human | |
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Location: | 17q23.1 |
Sequence: | 17; NC_000017.11 (60149942..60179021) |
Expressed in the endothelium of the choriocapillaris in eyes (at protein level). Not expressed in the retinal epithelium at detectable levels.
Cell membrane; Lipid-anchor, GPI-anchor.
PMID: 1311094 by Okuyama T., et al. Human carbonic anhydrase IV: cDNA cloning, sequence comparison, and expression in COS cell membranes.
PMID: 8325641 by Okuyama T., et al. Genomic organization and localization of gene for human carbonic anhydrase IV to chromosome 17q.