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- Table of Contents
Facts about C2 domain-containing protein 3.
Not required for centriolar satellite integrity or RAB8 activation. Required for primary cilium formation (PubMed:23769972).
Human | |
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Gene Name: | C2CD3 |
Uniprot: | Q4AC94 |
Entrez: | 26005 |
Belongs to: |
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No superfamily |
C2 calcium-dependent domain containing 3; C2CD3
Mass (kDA):
260.389 kDA
Human | |
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Location: | 11q13.4 |
Sequence: | 11; NC_000011.10 (74012578..74171210, complement) |
Cytoplasm, cytoskeleton, cilium basal body. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole. Localizes to centrioles and procentrioles both in interphase and mitosis. Localizes to centriolar satellites, localization is dependent on PCM1 and dynein-mediated retrograde transport. Also localizes to the distal ends of the mother and daughter centrioles.
PMID: 23769972 by Balestra F.R., et al. Discovering regulators of centriole biogenesis through siRNA-based functional genomics in human cells.
PMID: 24997988 by Thauvin-Robinet C., et al. The oral-facial-digital syndrome gene C2CD3 encodes a positive regulator of centriole elongation.