Biogenesis of lysosome-related organelles complex 1 subunit 6 (Bloc1s6)

Part of the BLOC-1 complex, a complex that is required for normal biogenesis of lysosome-related organelles (LRO), such as platelet dense granules and melanosomes. In concert with the AP-3 complex, the BLOC-1 complex is needed to target membrane protein cargos into vesicles constructed at cell bodies for delivery into neurites and nerve terminals.

The BLOC-1 complex, in association with SNARE proteins, is also suggested to be involved in neurite extension. May play a role in intracellular vesicle trafficking, particularly in the vesicle-docking and fusion procedure.