Basigin Antibodies

Basigin (BSG)

Plays an important role in targeting the monocarboxylate transporters SLC16A1, SLC16A3, SLC16A8 and SLC16A11 into the plasma membrane. Plays pivotal roles in spermatogenesis, embryo implantation, neural network formation and tumor development.

Stimulates adjacent fibroblasts to produce matrix metalloproteinases (MMPS). Seems to be a receptor for oligomannosidic glycans.

Gene Information

Human
Gene Name:	BSG
Uniprot:	P35613
Entrez:	682

Family

Belongs to:
No superfamily

Alternative Names

5F7; basigin (Ok blood group); Basigin; BSG; CD147 antigen; CD147; Collagenase stimulatory factor; EMMPRIN; EMMPRINTCSF; Extracellular matrix metalloproteinase inducer; Leukocyte activation antigen M6; M6; OK blood group antigen; OK; Tumor cell-derived collagenase stimulatory factor

Molecular Weight

Mass (kDA):
42.2 kDA

Genomic Context

Human
Location:	19p13.3
Sequence:	19; NC_000019.10 (571283..583493)

Tissue Specificity

Present only in vascular endothelium in non- neoplastic regions of the brain, whereas it is present in tumor cells but not in proliferating blood vessels in malignant gliomas.

Subcellular Localizations

Cell membrane; Single-pass type I membrane protein. Melanosome. Identified by mass spectrometry in melanosome fractions from stage I to stage IV. In spermatozoa, localized on the principal piece of caput and in the middle piece during transit in the corpus and cauda epididymides (By similarity).

Diseases

• Neoplasms
• Malignant Neoplasms
• Cell Invasion
• Carcinoma
• Neoplasm Metastasis
• Malignant Paraganglionic Neoplasm
• Neoplasm Invasiveness
• Tissue Adhesions
• Inflammation
• Tumor Progression
• Liver Carcinoma
• Malignant Squamous Cell Neoplasm
• Mammary Neoplasms

• Liver Neoplasms
• Nervousness
• Malignant Neoplasm Of Breast
• Nerve Degeneration
• Adenocarcinoma
• Gliosis
• Tumor Angiogenesis

Interacting Proteins

• APP
• HOOK1
• Slc16a1

Pathways

• Localization
• Secretion
• Cell Death
• Cell Proliferation
• Transport
• Angiogenesis
• Cell Adhesion
• Pathogenesis
• Glycosylation
• Rna Interference
• Cell Migration
• Regeneration
• Fermentation

• Spermatogenesis
• Chemotaxis
• Phagocytosis
• Cell Growth
• Inflammatory Response
• Cell Activation
• Tissue Remodeling

PTMs

• Carboxylation
• Glycosylation
• Phosphorylation
• Cleavage
• Deglycosylation
• Oxidation

• Demethylation
• Biotinylation
• Nitration
• Reduction
• Acetylation
• Methylation

• Ubiquitination

Research Areas

• Cancer
• Signal Transduction
• Vision

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/BSG

Best Uses Of The BSG Marker

Scientists can submit results using Boster Bio's primary-secondary-ABC system to find proteins with low background and high specificity. Researchers can also share their findings through applications and specific samples to earn product credits. Researchers from all over the globe can utilize this biomarker. This is a list of the top applications of the BSG marker. If you'd like to know more about this unique marker, read on!

Boster Bio's primary-secondary-ABC system allows researchers to locate proteins with low background and high specificity

This method uses avidins conjugated to signal molecules (usually Horseradish Peroxide, HRP) to find and identify specific proteins. It has a low background and high specificity. Similar detection systems have been created using organic polymers and polysaccharides. Boster Bio's Super Vision Detection Kit is one of the most ingenious detection techniques.

Researchers can also use this system to find biomarkers that are based on proteins. Glycosylation is a frequent post-translational modification to proteins, and more than 50% of proteins found in cells of eukaryotes are glycoproteins. Glycoproteins play an essential role in cell signaling and immune recognition, as well as interactions between cells. Many proteins are routinely identified in diagnostic tests like Alpha-fetoprotein AFP and many other illnesses.

The sensitivities of the system depend on the type of protein to be detected. The sensitivity of transferred proteins is affected by the membrane used. A high-molecular-weight membrane has a greater binding capacity for low and medium-molecular-weight proteins than one made of polyvinylidene fluoride.

The company has raised over $50 million from a variety of investors. The company plans to hire two dozen full-time employees during a series B round that will be held in December 2021. Peter Gabriel, Formic Ventures and Formic Ventures are other investors. Although the company is still a start-up, it's already able to raise more than $54 million.

Scripps Research scientists recently used this technology to identify the underlying causes of the disease. The San Diego County man, who had not traveled recently was not a traveler and was showing mild symptoms at the time of testing. He did not require hospitalization following the tests. He had received an additional vaccine two weeks prior to the time the infection was diagnosed.

Because the primary-secondary-ABC system is capable of detecting a protein with a low background, it is highly efficient at locating proteins. It can also be used for identifying the re-probed proteins. These two methods are particularly useful when the protein is low molecular weight. These methods provide reliable results, which allows researchers to be confident in identifying proteins with high specificity and low background.

This method has many uses in medicine. Two million neurons die when blood flow ceases in the brain after an injury such as a stroke. Patients suffering from severe cases should be referred to specialist hospitals, where an imaging scan will permit a full diagnosis. Openwater will respond in an ambulance to patients suffering from these conditions. With the help of a headband that is innovative, the device detects a major vessel obstruction and diverts blood flow away from the entire hemisphere of the brain. It will direct first responders to the right stroke center.

The company also offers organs-on-achip technology that can detect and detect potential harmful substances. The unique features of the system could lead to fewer harmful substances advancing through the clinical trials process. Researchers can now easily identify the substances that are safe and which ones can be harmful to humans using this technology. In addition to the benefits of this system, it can help biotech companies decide which drugs to develop. It could also help eliminate drugs that can cause liver damage.

Boster Bio's Super Vision Detection kits allows researchers to identify proteins that have a low background and high specificity

HostDx Sepsis is the company's most sophisticated product. It is currently being tested in various U.S. hospitals and will be approved by the FDA in the middle of next. It can detect potential toxins such as benzene , which is the cause of 7% of worldwide's burden of disease. The company hopes to apply its technology to the study of antibiotic resistance which is not considered "sexy," but is essential to understand the connection between work and health.

The company's ELISA detection kits and WB detection kits are optimized for IHC, WB and Flow Cytometry. With a low background and high specificity, researchers can identify proteins that are deeply embedded in cells and tissues. ELISA is also compatible with Supervision detection kits. Contact the product's validation procedure for images and procedure.

Diagnostic BioSystems offers advanced polymer and streptavidin/biotin-based immunohistochemistry detection methods. The products are available in five colors and include two enzyme labels. The company also provides a range of ancillary products including background blockers, mounting media as well as antigen retrieval strategies and counter stains.

The primary-secondary-ABC system identifies proteins of interest by combining avidins with signal molecules. This system is extremely adaptable and has high specificity and low background. Other detection systems are based on polysaccharides and organic polymers. These systems make it easier to identify proteins in complex samples. Super vision detection kits are the most recent examples of such a revolutionary detection systems.

The company's Super Vision detection kits allow researchers to detect and locate proteins that have low background and high specificity. These kits are specifically designed for researchers who need to identify specific proteins in complex samples. They are highly sensitive and specific, making them useful to a variety of research applications. They can help researchers find proteins with low background Boster Bio’s Super Vision detection kit.

Finding novel drugs is difficult due to the need find more effective antimicrobial resistance treatments. A new technology called Super Vision can pinpoint specific proteins by the detection of low-level background and high-specific messenger RNA. It could help researchers determine which drug to prescribe to patients and even diagnose illnesses such as liver cancer. Super Vision can detect antimicrobial resistance and messenger RNA. This code is used to find sites for protein synthesizing.

Boster Bio Anti-CD147/BSG Antibody

Anti-CD147 antibodies are available for a range of applications, including ELISA, IHC-P, and WB. Boster Bio has developed a variety of ELISA kits for the detection of biomarkers in a variety of fields, such as neurosciences, cancer, and inflammation. The antibody can detect levels that go up to the size of a picogram BSG and is available at Tebu-bio. a reputable supplier of research antibodies.

Boster Bio Anti CD147/BSGAbs is an antibody monoclonal that targets the BSG marker. The molecular marker is found on B cells. BSG is an essential nuclear protein that plays a crucial role in the process of spermatogenesis. It also stimulates adjacent fibroblasts and fibroblasts to produce matrix metalloproteinases. Additionally, BSG is an important component of the Ok blood group system. It has been shown to be a key malaria parasite receptor on red blood cells. It is a member of the immunoglobulin superfamily. It has a structure that is similar to the primordial form.

Boster Bio Anti-CD147/BSg antibody works by using the BSG marker to determine the expression of the CD147 gene. ELISA is a relatively simple procedure. Cells were harvested and then subjected three cycles of freezing and then thawing at -80°C. The total protein was separated by using a 10 SDS/PADE gel. The membrane was blocked using 5 percent skimmed dairy powder and incubated over 2 hours under closed conditions. The protein was then incubated in rabbit anti-human CD147 primary antibodies (1,500) and PE-Ac-1 which was conjugated to horseradish oxide. Following this, the membrane was analyzed using DAPI, Streptavidin and Chroma

In addition to regulating the growth and spread of colon cancer cells, CD147 has been shown to reduce the expression of the GSDMD and Ki-67 markers in colon cancer cells. GSDMD overexpression caused this inhibitory effect to vanish. This suggests that the overexpression of CD147 could be associated with a poor prognosis and poor survival.

The antibody can also detect the expression of the BSG marker which is present in some cancerous cells. This BSG marker is expressed extensively by various types of cancer which includes BC. It is also referred to as BSG and is part of the immunoglobulin superfamily. It is present in both soluble and as transmembrane forms in tumors. It is not yet clear what function it performs in cancer cells but it is believed to play an important role in the growth of tumors.

Recombinant adenovirus (recombinant siRNA) is a different method to target CD147. It blocks LOI cells both in vitro and in living. Recombinant adenovirus is able to carry IGF2 imprinting, which may be the reason for why it blocks the growth of LOI colon cancer cells.