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- Table of Contents
, No Gclids
Seipin Antibodies
AND Bscl2 ELISA kits, Seipin Proteins
Many biological assays use antibodies to detect Seipin, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Seipin in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Seipin antibodies...
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Bscl2 Overview
Facts about Seipin.
Seipin (Bscl2)
Is a regulator of lipid catabolism essential for adipocyte differentiation. Necessary for correct lipid storage and lipid droplets maintenance; may play a tissue-autonomous role in controlling lipid storage in adipocytes and in preventing ectopic lipid droplet formation in non-adipose tissues.
May also be involved in the central regulation of energy homeostasis. .
Gene Information
| Mouse | |
|---|---|
| Gene Name: | Bscl2 |
| Uniprot: | Q9Z2E9 |
| Entrez: | 14705 |
Family
| Belongs to: |
|---|
| seipin family |
Alternative Names
Berardinelli-Seip congenital lipodystrophy 2 (seipin); Bernardinelli-Seip congenital lipodystrophy 2 (seipin); Bernardinelli-Seip congenital lipodystrophy type 2 protein; BSCL2; FLJ16651; GNG3LG; HMN5; MGC4694; Seipin; spastic paraplegia 17 (Silver syndrome); SPG17
Molecular Weight
Mass (kDA):
43.105 kDA
Genomic Context
| Mouse | |
|---|---|
| Location: | 19 A|19 5.76 cM |
| Sequence: | 19; |
Tissue Specificity
Expressed in the paraventricular nucleus of the hypothalamus (PVN) and brainstem dorsal vagal complex (DVC) in oxytocin and catecholaminergic neurons (at protein level). Highest expression detected in subcutaneous and epididymal white adipose tissue, brown adipose tissue and testis. Also expressed in brain, skeletal muscle and adrenal gland, with lower levels detected in liver, heart, kidney, spleen, lung and small intestine. In brain, detected in piriform cortex, olfactory tubercle, islands of Calleja, lateral septal nucleus, medial septal nucleus, nucleus of the vertical limb of the diagonal band, nucleus of the horizontal limb of the diagonal band, preoptic area, paraventricular thalamic nucleus, lateral globus pallidus, supraoptic nucleus, suprachiasmatic nucleus, subfornical organ, paraventricular nucleus of the hypothalamus, zona incerta, dorsomedial nucleus of the hypothalamus, ventromedial nucleus of the hypothalamus, arcuate nucleus of the hypothalamus, basomedial amygdaloid nucleus, medial amygdaloid nucleus, medial habenular, pyramidal cell layer of the hippocampus, granular layer of the dentate gyrus, posterior hypothalamus, supramammilliary nucleus, premammillary nucle
Diseases
- Lipodystrophy
- Familial Generalized Lipodystrophy
- Insulin Resistance
- Diabetes Mellitus
- Peripheral Motor Neuropathy
- Myeloid Leukemia, Chronic
- Paraplegia
- Russell-silver Syndrome
- Motor Neuron Disease
- Hereditary Motor And Sensory Neuropathies
- Spastic Paraplegia
Pathways
- Pathogenesis
- Cell Death
- Localization
- Lipid Storage
- Transport
- Glycosylation
- Adipose Tissue Development
- Tissue Development
- Aging
- Muscle Hypertrophy
- Rna Processing
- Insulin Secretion
- Neuron Development
PTMs
- Glycosylation
- Ubiquitination
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/Bscl2
bosterbio.com/bosterbio-gene-info-cards/Bscl2
References
PMID: 9790771 by Downes G.B., et al. Structure and mapping of the G protein gamma3 subunit gene and a divergently transcribed novel gene, Gng3lg.
PMID: 10679242 by Inoue S., et al. Growth suppression of Escherichia coli by induction of expression of mammalian genes with transmembrane or ATPase domains.