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BRCA2 Antibodies
AND BRCA2 ELISA kits, BRCA2 Proteins
Many biological assays use antibodies to detect BRCA2, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with BRCA2 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop BRCA2 antibodies...
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BRCA2 Overview
Facts about Breast cancer type 2 susceptibility protein.
Breast cancer type 2 susceptibility protein (BRCA2)
Involved in double-strand fracture repair and/or homologous recombination. Binds RAD51 and potentiates recombinational DNA repair by promoting assembly of RAD51 onto single-stranded DNA (ssDNA).
Acts by targeting RAD51 to ssDNA over double-stranded DNA, allowing RAD51 to displace replication protein-A (RPA) from ssDNA and stabilizing RAD51-ssDNA filaments by blocking ATP hydrolysis. Section of a PALB2-scaffolded HR complex containing RAD51C and which is thought to play a role in DNA repair by HR.
Gene Information
| Human | |
|---|---|
| Gene Name: | BRCA2 |
| Uniprot: | P51587 |
| Entrez: | 675 |
Family
| Belongs to: |
|---|
| No superfamily |
Alternative Names
BRCA1/BRCA2-containing complex, subunit 2; BRCA2; BRCC2; breast and ovarian cancer susceptibility gene, early onset; breast cancer 2 tumor suppressor; breast cancer 2, early onset; breast cancer susceptibility protein BRCA2; breast cancer type 2 susceptibility protein; BROVCA2; FACD; FAD; FAD1; FANCB; FANCD; FANCD1Fanconi anemia, complementation group D1; Fanconi anemia group D1 protein; GLM3; PNCA2
Molecular Weight
Mass (kDA):
384.202 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 13q13.1 |
| Sequence: | 13; NC_000013.11 (32315508..32400268) |
Tissue Specificity
Highest levels of expression in breast and thymus, with slightly lower levels in lung, ovary and spleen.
Subcellular Localizations
Nucleus. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome.
Diseases
- Malignant Neoplasms
- Mammary Neoplasms
- Malignant Neoplasm Of Breast
- Neoplasms
- Malignant Neoplasm Of Ovary
- Ovarian Neoplasm
- Brca2 Gene Mutation
- Carcinoma
- Brca1 Gene Mutation
- Hereditary Breast Carcinoma
- Cell Transformation, Neoplastic
- Anemia
- Breast Neoplasms, Male
Interacting Proteins
- DMC1
- FANCD2
- HMG20B
- PALB2
- PDS5B
- POLH
- RAD51
- SEM1
- TP53
Pathways
- Dna Repair
- Cell Cycle
- Pathogenesis
- Localization
- Hypersensitivity
- Methylation
- Cell Proliferation
- Double-strand Break Repair
- Dna Replication
- Mismatch Repair
- Cell Growth
- Cell Death
- Meiosis
PTMs
- Methylation
- Phosphorylation
- Ubiquitination
- Cleavage
- Acetylation
Research Areas
- Breast Cancer
- Cancer
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/BRCA2
bosterbio.com/bosterbio-gene-info-cards/BRCA2
References
PMID: 8524414 by Wooster R., et al. Identification of the breast cancer susceptibility gene BRCA2.
PMID: 8589730 by Tavtigian S.V., et al. The complete BRCA2 gene and mutations in chromosome 13q-linked kindreds.