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Bmp10 Antibodies
AND Bmp10 ELISA kits, Bmp10 Proteins
Many biological assays use antibodies to detect Bmp10, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Bmp10 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Bmp10 antibodies...
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Bmp10 Infographic by Boster Bio
All Bmp10 Products
Product
Figures
Specificity
Applications
Price
Human
ELISA
$750
Cat # EK1808
96 wells/kit, with removable strips.
Cat # EK1808
96 wells/kit, with removable strips.
Mouse
ELISA
$750
Cat # EK1809
96 wells/kit, with removable strips.
Cat # EK1809
96 wells/kit, with removable strips.
Rat BMP-10 ELISA Kit PicoKine®
10 Q&As
Rat
ELISA
$750
Cat # EK1810
96 wells/kit, with removable strips.
Cat # EK1810
96 wells/kit, with removable strips.
Human
Cell Culture
$77
Cat # PROTO95393-2
5ug,20ug,100ug
Cat # PROTO95393-2
5ug,20ug,100ug
Bmp10 Overview
Facts about Bone morphogenetic protein 10.
Bone morphogenetic protein 10 (Bmp10)
Required for maintaining the proliferative activity of embryonic cardiomyocytes by preventing premature activation of the negative cell cycle regulator CDKN1C/p57KIP and maintaining the required expression levels of cardiogenic factors like MEF2C and NKX2-5. Acts as a ligand for ACVRL1/ALK1, BMPR1A/ALK3 and BMPR1B/ALK6, leading to activation of SMAD1, SMAD5 and SMAD8 transcription factors.
Inhibits endothelial cell migration and development. May reduce cell migration and cell matrix adhesion in breast cancer cell lines (By similarity).
Gene Information
| Mouse | |
|---|---|
| Gene Name: | Bmp10 |
| Uniprot: | Q9R229 |
| Entrez: | 12154 |
Family
| Belongs to: |
|---|
| TGF-beta family |
Alternative Names
BMP10; BMP-10; bone morphogenetic protein 10; MGC126783
Molecular Weight
Mass (kDA):
47.888 kDA
Genomic Context
| Mouse | |
|---|---|
| Location: | 6|6 D1 |
| Sequence: | 6; |
Tissue Specificity
In the embryo, expressed exclusively in the ventricular trabecular myocardium of the developing heart from E9.0-E13.5. By E16.5-E18.5, only detectable in atria. Highly expressed in the adult heart where it is found in the right atrium but not in the left atrium. Lower levels in adult liver and lung.
Diseases
- Tumor Angiogenesis
- Neoplasms
- Hereditary Hemorrhagic Telangiectasia
- Malignant Neoplasms
- Ventricular Septal Defects
- Pathologic Neovascularization
- Telangiectasis
- Heart Diseases
- Hypertrophy
- Congenital Heart Defects
- Heart Septal Defects
- Cardiomyopathies
Pathways
- Angiogenesis
- Heart Development
- Cell Cycle
- Cell Migration
- Cell Proliferation
- Pathogenesis
- Immune Response
- Endothelial Cell Migration
- Programmed Cell Death
- Adaptive Immune Response
- Cardiac Conduction
- Heart Formation
- Cell Differentiation
PTMs
- Phosphorylation
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/Bmp10
bosterbio.com/bosterbio-gene-info-cards/Bmp10
References
PMID: 10072785 by Neuhaus H., et al. Heart specific expression of mouse BMP-10 a novel member of the TGF- beta superfamily.
PMID: 15109497 by Pashmforoush M., et al. Nkx2-5 pathways and congenital heart disease: loss of ventricular myocyte lineage specification leads to progressive cardiomyopathy and complete heart block.