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, No Gclids
BCL10 Antibodies
AND BCL10 ELISA kits, BCL10 Proteins
Many biological assays use antibodies to detect BCL10, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with BCL10 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop BCL10 antibodies...
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BCL10 Infographic by Boster Bio
All BCL10 Products
Product
Figures
Specificity
Applications
Price
Human, Mouse, Rat
WB
$370
Cat # PA1504
100 μg/vial
Cat # PA1504
100 μg/vial
Human, Mouse, Rat
WB
$523
Cat # M01616-2
100 µl
Cat # M01616-2
100 µl
BCL10 Overview
Facts about B-cell lymphoma/leukemia 10.
B-cell lymphoma/leukemia 10 (BCL10)
Involved in adaptive immune response (PubMed:25365219). Promotes apoptosis, pro-caspase-9 maturation and activation of NF- kappa-B via NIK and IKK.
May be an adapter protein involving upstream TNFR1-TRADD-RIP complex and the downstream NIK-IKK-IKAP complex. Is a substrate for MALT1 (PubMed:18264101).
Gene Information
| Human | |
|---|---|
| Gene Name: | BCL10 |
| Uniprot: | O95999 |
| Entrez: | 8915 |
Family
| Belongs to: |
|---|
| No superfamily |
Alternative Names
B-cell CLL/lymphoma 10CIPERCLAPB-cell lymphoma/leukemia 10; Bcl10; Bcl-10; CARD-containing apoptotic signaling protein; CARD-containing molecule enhancing NF-kappa-B; CARD-containing proapoptotic protein; CARD-like apoptotic protein; CARMEN; caspase-recruiting domain-containing protein; cCARMEN; c-E10; c-E10bcl-10; CED-3/ICH-1 prodomain homologous E10-like regulator; Cellular homolog of vCARMEN; cellular-E10; CIPER; CLAP; hCLAP; Mammalian CARD-containing adapter molecule E10; mE10; mE10CARD containing molecule enhancing NF-kB
Molecular Weight
Mass (kDA):
26.252 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 1p22.3 |
| Sequence: | 1; NC_000001.11 (85265776..85276632, complement) |
Tissue Specificity
Ubiquitous.
Subcellular Localizations
Cytoplasm, perinuclear region. Membrane raft. Appears to have a perinuclear, compact and filamentous pattern of expression. Also found in the nucleus of several types of tumor cells. Colocalized with DPP4 in membrane rafts.
Diseases
- Lymphoma
- Mucosa-associated Lymphoid Tissue Lymphoma
- Marginal Zone B-cell Lymphoma
- Neoplasms
- B-cell Lymphomas
- Chromosomal Translocation
- Malignant Neoplasms
- T(11;18)(q21;q21)
- Diffuse Large B-cell Lymphoma
- Stomach Neoplasms
- Inflammation
- Carcinoma
Interacting Proteins
- AKT1
- BCL3
- CARD11
- CARD9
- COG6
- IKBKG
- MALT1
- PRKCZ
- TRAF2
Pathways
- Pathogenesis
- Cell Activation
- Cytokine Production
- Immune Response
- T Cell Activation
- Secretion
- Localization
- Lymphocyte Activation
- Cell Death
- Adaptive Immune Response
- Interphase
- Cell Proliferation
- Rna Interference
PTMs
- Phosphorylation
- Ubiquitination
- Cleavage
Research Areas
- Apoptosis
- Cancer
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/BCL10
bosterbio.com/bosterbio-gene-info-cards/BCL10
References
PMID: 9989495 by Willis T.G., et al. Bcl10 is involved in t(1;14)(p22;q32) of MALT B cell lymphoma and mutated in multiple tumor types.
PMID: 10187770 by Koseki T., et al. CIPER, a novel NF kappaB-activating protein containing a caspase recruitment domain with homology to Herpesvirus-2 protein E10.