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BAP1 Antibodies
AND BAP1 ELISA kits, BAP1 Proteins
Many biological assays use antibodies to detect BAP1, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with BAP1 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop BAP1 antibodies...
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BAP1 Overview
Facts about Ubiquitin carboxyl-terminal hydrolase BAP1.
Ubiquitin carboxyl-terminal hydrolase BAP1 (BAP1)
Deubiquitinating enzyme that plays an integral role in chromatin by mediating deubiquitination of histone H2A and HCFC1. Catalytic component of the PR-DUB complex, a complex that specifically mediates deubiquitination of histone H2A monoubiquitinated at'Lys-119' (H2AK119ub1).
Does not deubiquitinate monoubiquitinated histone H2B. Acts as a regulator of cell growth by mediating deubiquitination of HCFC1 N-terminal and C-terminal chains, with some specificity toward'Lys-48'- linked polyubiquitin chains in contrast to'Lys-63'-linked polyubiquitin chains.
Gene Information
| Human | |
|---|---|
| Gene Name: | BAP1 |
| Uniprot: | Q92560 |
| Entrez: | 8314 |
Family
| Belongs to: |
|---|
| peptidase C12 family |
Alternative Names
BAP1; BRCA1 associated protein-1 (ubiquitin carboxy-terminal hydrolase); BRCA1-associated protein 1; Cerebral protein 6; cerebral protein-13; Cerebral Protein-6; DKFZp686N04275; EC 3.4.19.12; FLJ35406; FLJ37180; hucep-6; KIAA0272HUCEP-13; ubiquitin carboxyl-terminal hydrolase BAP1; ubiquitin carboxy-terminal hydrolase; UCHL2
Molecular Weight
Mass (kDA):
80.362 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 3p21.1 |
| Sequence: | 3; NC_000003.12 (52401004..52410030, complement) |
Tissue Specificity
Highly expressed in testis, placenta and ovary. Expressed in breast.
Subcellular Localizations
Cytoplasm. Nucleus. Mainly nuclear. Binds to chromatin. Localizes to the cytoplasm when monoubiquitinated by the E2/E3 hybrid ubiquitin-protein ligase UBE2O (PubMed:24703950).
Diseases
- Neoplasms
- Malignant Neoplasms
- Melanoma
- Carcinoma
- Malignant Paraganglionic Neoplasm
- Uveal Melanoma
- Mammary Neoplasms
- Mesothelioma
- Uveal Neoplasms
- Neoplasm Metastasis
- Malignant Neoplasm Of Breast
- Malignant Neoplasm Of Lung
- Cell Transformation, Neoplastic
Interacting Proteins
- ASXL1
- BRCA1
- HCFC1
- ITPR3
Pathways
- Cell Cycle
- Cell Proliferation
- Localization
- Pathogenesis
- Cell Growth
- Cell Division
- Dna Repair
- Transport
- Cell Death
- Cell Adhesion
- Disease Resistance
- Gene Silencing
- Chemotaxis
PTMs
- Ubiquitination
- Phosphorylation
- Methylation
- Demethylation
- Reduction
Research Areas
- Apoptosis
- Breast Cancer
- Cancer
- Cell Cycle and Replication
- Chromatin Research
- DNA Repair
- Tumor Suppressors
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/BAP1
bosterbio.com/bosterbio-gene-info-cards/BAP1
References
PMID: 9528852 by Jensen D.E., et al. BAP1: a novel ubiquitin hydrolase which binds to the BRCA1 RING finger and enhances BRCA1-mediated cell growth suppression.
PMID: 12800201 by Behrends U., et al. Novel tumor antigens identified by autologous antibody screening of childhood medulloblastoma cDNA libraries.