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- Table of Contents
Facts about Barrier-to-autointegration factor.
Contains 2 non-specific dsDNA-binding sites which may promote DNA cross-bridging. .
Human | |
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Gene Name: | BANF1 |
Uniprot: | O75531 |
Entrez: | 8815 |
Belongs to: |
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BAF family |
BAFMGC111161; barrier to autointegration factor 1; barrier-to-autointegration factor; BCRG1; BCRP1; Breakpoint cluster region protein 1; D14S1460
Mass (kDA):
10.059 kDA
Human | |
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Location: | 11q13.1 |
Sequence: | 11; NC_000011.10 (66002079..66004149) |
Widely expressed. Expressed in colon, brain, heart, kidney, liver, lung, ovary, pancreas, placenta, prostate, skeletal muscle, small intestine, spleen and testis. Not detected in thymus and peripheral blood leukocytes.
[Barrier-to-autointegration factor]: Nucleus. Cytoplasm. Chromosome. Nucleus envelope. Significantly enriched at the nuclear inner membrane, diffusely throughout the nucleus during interphase and concentrated at the chromosomes during the M-phase. The phosphorylated form (by VRK1 or vaccinia virus B1 kinase) shows a cytoplasmic localization whereas the unphosphorylated form locates almost exclusively in the nucleus (PubMed:24600006, PubMed:16495336). May be included in HIV-1 virions via its interaction with viral GAG polyprotein.
PMID: 9465049 by Lee M.S., et al. A previously unidentified host protein protects retroviral DNA from autointegration.
PMID: 9740667 by Lynch R.A., et al. Genomic and functional map of the chromosome 14 t(12;14) breakpoint cluster region in uterine leiomyoma.