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BAG3 Antibodies
AND BAG3 ELISA kits, BAG3 Proteins
Many biological assays use antibodies to detect BAG3, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with BAG3 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop BAG3 antibodies...
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BAG3 Overview
Facts about BAG family molecular chaperone regulator 3.
BAG family molecular chaperone regulator 3 (BAG3)
Co-chaperone for HSP70 and HSC70 chaperone proteins.
Acts as a nucleotide-exchange factor (NEF) promoting the release of ADP in the HSP70 and HSC70 proteins thereby triggering client/substrate protein release.Nucleotide release is mediated through its binding to the nucleotide-binding domain (NBD) of HSPA8/HSC70 where as the substrate release is mediated through its binding to the substrate-binding domain (SBD) of HSPA8/HSC70 (PubMed:9873016, PubMed:27474739). Has anti-apoptotic activity (PubMed:10597216).
Gene Information
| Human | |
|---|---|
| Gene Name: | BAG3 |
| Uniprot: | O95817 |
| Entrez: | 9531 |
Family
| Belongs to: |
|---|
| No superfamily |
Alternative Names
BAG family molecular chaperone regulator 3; BAG-3; BAG-family molecular chaperone regulator-3; Bcl-2-associated athanogene 3; BCL2-associated athanogene 3; BCL2-binding athanogene 3; Bcl-2-binding protein Bis; BIS; CAIR-1; Docking protein CAIR-1; MGC104307
Molecular Weight
Mass (kDA):
61.595 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 10q26.11 |
| Sequence: | 10; NC_000010.11 (119651380..119677819) |
Subcellular Localizations
Nucleus. Cytoplasm. Colocalizes with HSF1 to the nucleus upon heat stress (PubMed:26159920).
Diseases
- Malignant Neoplasms
- Neoplasms
- Myopathy
- Leukemia
- Cardiomyopathies
- Carcinoma
- Muscular Dystrophy
- Weakness
- Tissue Adhesions
- Neoplasm Invasiveness
- Muscle Weakness
- Neoplasm Metastasis
Interacting Proteins
- ARRDC3
- DAZAP2
- HSPB1
- HSPB8
- LITAF
- LRRK2
- MAGED1
- PDE9A
- PDLIM7
- SF3B4
Pathways
- Cell Death
- Autophagy
- Cell Adhesion
- Macroautophagy
- Pathogenesis
- Cell Proliferation
- Cell Growth
- Cell Motility
- Protein Folding
- Transport
- Cell Cycle
- Aging
- Proteolysis
PTMs
- Phosphorylation
- Cleavage
- Ubiquitination
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/BAG3
bosterbio.com/bosterbio-gene-info-cards/BAG3
References
PMID: 9873016 by Takayama S., et al. An evolutionarily conserved family of Hsp70/Hsc70 molecular chaperone regulators.
PMID: 10597216 by Lee J.H., et al. Bis, a Bcl-2-binding protein that synergizes with Bcl-2 in preventing cell death.