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- Table of Contents
Facts about BRISC and BRCA1-A complex member 1.
In the BRCA1-A complex, it is required for the complex integrity and its localization at DSBs. Component of the BRISC complex, a multiprotein complex that specifically cleaves'Lys- 63'-linked ubiquitin in a variety of substrates (PubMed:24075985, PubMed:26195665).
Human | |
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Gene Name: | BABAM1 |
Uniprot: | Q9NWV8 |
Entrez: | 29086 |
Belongs to: |
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BABAM1 family |
BABAM1; BRISC and BRCA1 A complex member 1; C10orf62; C19orf62; chromosome 19 open reading frame 62; FLJ20571; HSPC142; mediator of Rap80 interactions and targeting 40 kDa; Mediator of RAP80 interactions and targeting subunit of 40 kDa; MERIT40; MERIT40BRCA1-A complex subunit MERIT40; NBA1; NBA1BRISC and BRCA1 A complex member; new component of the BRCA1 A complex; New component of the BRCA1-A complex; new component of the BRCAA1 A complex
Mass (kDA):
36.56 kDA
Human | |
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Location: | 19p13.11 |
Sequence: | 19; NC_000019.10 (17267376..17279353) |
Cytoplasm. Nucleus. Localizes at sites of DNA damage at double-strand breaks (DSBs).
PMID: 19214193 by Cooper E.M., et al. K63-specific deubiquitination by two JAMM/MPN+ complexes: BRISC- associated Brcc36 and proteasomal Poh1.
PMID: 19261746 by Shao G., et al. MERIT40 controls BRCA1-Rap80 complex integrity and recruitment to DNA double-strand breaks.