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ATP11A Antibodies
AND ATP11A ELISA kits, ATP11A Proteins
Many biological assays use antibodies to detect ATP11A, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with ATP11A in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop ATP11A antibodies...
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ATP11A Overview
Facts about Probable phospholipid-transporting ATPase IH.
Probable phospholipid-transporting ATPase IH (ATP11A)
Catalytic component of a P4-ATPase flippase complex which catalyzes the hydrolysis of ATP coupled to the transport of aminophospholipids from the outer to the inner leaflet of various membranes and ensures the maintenance of asymmetric distribution of phospholipids. Phospholipid translocation appears also to be implicated in vesicle formation and in uptake of lipid signaling molecules (Probable).
May be involved in the uptake of farnesyltransferase inhibitor drugs, such as lonafarnib. .
Gene Information
| Human | |
|---|---|
| Gene Name: | ATP11A |
| Uniprot: | P98196 |
| Entrez: | 23250 |
Family
| Belongs to: |
|---|
| cation transport ATPase (P-type) (TC 3.A.3) family |
Alternative Names
ATPase, class VI, type 11A
Molecular Weight
Mass (kDA):
129.756 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 13q34 |
| Sequence: | 13; NC_000013.11 (112690034..112887168) |
Subcellular Localizations
Cell membrane; Multi-pass membrane protein. Early endosome. Recycling endosome. Endoplasmic reticulum. Exit from the endoplasmic reticulum requires the presence of TMEM30A, but not TMEM30B. In the presence of TMEM30A, predominantly located in the plasma membrane.
Diseases
- Diabetes Mellitus
- Adenocarcinoma
- Neoplasm Metastasis
- Anemia
- Hypoparathyroidism
- Neoplasms, Second Primary
- Malignant Paraganglionic Neoplasm
- Acute Lymphocytic Leukemia
- Diabetes Mellitus, Non-insulin-dependent
- Malignant Neoplasms
Pathways
- Transport
- Drug Resistance
- Golgi Localization
- Protein Transport
- Phospholipid Translocation
- Localization
PTMs
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/ATP11A
bosterbio.com/bosterbio-gene-info-cards/ATP11A
References
PMID: 15860663 by Zhang B., et al. Resistance to farnesyltransferase inhibitors in Bcr/Abl-positive lymphoblastic leukemia by increased expression of a novel ABC transporter homolog ATP11a.
PMID: 21914794 by Takatsu H., et al. ATP9B, a P4-ATPase (a putative aminophospholipid translocase), localizes to the trans-Golgi network in a CDC50 protein-independent manner.