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Asap1 Antibodies
AND Asap1 ELISA kits, Asap1 Proteins
Many biological assays use antibodies to detect Asap1, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Asap1 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Asap1 antibodies...
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Asap1 Overview
Facts about Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1.
Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1 (Asap1)
May function as a signal transduction protein involved in the differentiation of fibroblasts into adipocytes and possibly other cell types. Plays a role in ciliogenesis (By similarity).
Posseses phosphatidylinositol 4,5-bisphosphate-dependent GTPase- activating protein activity for ARF1 (ADP ribosylation factor 1) and ARF5 and a lesser action towards ARF6. May coordinate membrane trafficking with cell growth or actin cytoskeleton remodeling by binding to both SRC and PIP2.
Gene Information
| Mouse | |
|---|---|
| Gene Name: | Asap1 |
| Uniprot: | Q9QWY8 |
| Entrez: | 13196 |
Family
| Belongs to: |
|---|
| No superfamily |
Alternative Names
130 kDa phosphatidylinositol 4,5-biphosphate-dependent ARF1 GTPase-activatingprotein; AMAP1; ARF GTPase-activating protein 1; arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1; ArfGAP with SH3 domain, ankyrin repeat and PH domain 1; centaurin, beta 4; CENTB4; DDEF1ADP-ribosylation factor-directed GTPase-activating protein 1; development and differentiation enhancing factor 1; Development and differentiation-enhancing factor 1; Differentiation-enhancing factor 1; KIAA1249DEF-1; PAG2; PAP; PIP2-dependent ARF1 GAP; ZG14P
Molecular Weight
Mass (kDA):
127.421 kDA
Genomic Context
| Mouse | |
|---|---|
| Location: | 15|15 D1 |
| Sequence: | 15; |
Tissue Specificity
Expressed in all tissues examined but a most abundant expression was found in the testis, brain, lung and spleen. A heightened expression was seen in the adipose tissue from obese (ob) and diabetic (db) animals.
Diseases
- Neoplasms
- Malignant Neoplasms
- Cell Invasion
- Neoplasm Invasiveness
- Tissue Adhesions
- Neoplasm Metastasis
- Malignant Neoplasm Of Breast
- Mammary Neoplasms
- Fish Diseases
- Carcinoma
- Atypical Small Acinar Proliferation Of The Prostate Gland
- Carcinogenesis
- Neoplasm/cancer Invasiveness
Pathways
- Cell Migration
- Localization
- Transport
- Cell Motility
- Cell Adhesion
- Virulence
- Endocytosis
- Proteolysis
- Translation
- Exocytosis
- Pathogenesis
- Secretion
- Protein Phosphorylation
PTMs
- Ribosylation
- Phosphorylation
- Reduction
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/Asap1
bosterbio.com/bosterbio-gene-info-cards/Asap1
References
PMID: 9819391 by Brown M.T., et al. ASAP1, a phospholipid-dependent arf GTPase-activating protein that associates with and is phosphorylated by Src.
PMID: 9126384 by Yamabhai M., et al. Examining the specificity of Src homology 3 domain -- ligand interactions with alkaline phosphatase fusion proteins.