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, No Gclids
ARHGEF2 Antibodies
AND ARHGEF2 ELISA kits, ARHGEF2 Proteins
Many biological assays use antibodies to detect ARHGEF2, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with ARHGEF2 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop ARHGEF2 antibodies...
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ARHGEF2 Infographic by Boster Bio
All ARHGEF2 Products
Product
Figures
Specificity
Applications
Price
Human, Mouse, Rat
ELISA
$480
Cat # EKC1037
1 kit, containing one 96-well plate and all necessary reagents
Cat # EKC1037
1 kit, containing one 96-well plate and all necessary reagents
Human, Mouse, Rat
ELISA
$540
Cat # EKC2338
1 kit, containing two 96-well plates and all necessary reagents
Cat # EKC2338
1 kit, containing two 96-well plates and all necessary reagents
Human, Mouse, Rat
Flow Cytometry, IF, IHC, ICC, WB
$405
Cat # A02572-2
100ul
Cat # A02572-2
100ul
Human, Mouse, Rat
ELISA, IHC, WB
$380
Cat # A02572S885
100ul
Cat # A02572S885
100ul
Human, Mouse, Rat
Flow Cytometry, WB
$523
Cat # M02572
100 µl
Cat # M02572
100 µl
Human, Mouse, Rat
Flow Cytometry, IF, ICC, WB
$370
Cat # M02572-1
100 μl/vial
Cat # M02572-1
100 μl/vial
Human, Mouse, Rat
ELISA, Flow Cytometry, IHC, WB
$370
Cat # A02572-3
100 μg/vial
Cat # A02572-3
100 μg/vial
ARHGEF2 Overview
Facts about Rho guanine nucleotide exchange factor 2.
Rho guanine nucleotide exchange factor 2 (ARHGEF2)
Activates Rho-GTPases by Encouraging the exchange of GDP for GTP.
Might be involved in epithelial barrier permeability, cell motility and polarization, dendritic spine morphology, antigen presentation, leukemic cell differentiation, cell cycle regulation, innate immune response, and cancer.Binds Rac-GTPases, but doesn't seem to promote nucleotide exchange activity toward Rac-GTPases, which was uniquely reported in PubMed:9857026. May stimulate instead the cortical activity of Rac.
Gene Information
| Human | |
|---|---|
| Gene Name: | ARHGEF2 |
| Uniprot: | Q92974 |
| Entrez: | 9181 |
Family
| Belongs to: |
|---|
| No superfamily |
Alternative Names
GEF; GEFH1; GEF-H1DKFZp547P1516; Guanine nucleotide exchange factor H1; KIAA0651DKFZp547L106; LFP40FLJ45440; Microtubule-regulated Rho-GEF; P40; Proliferating cell nucleolar antigen p40; rho guanine nucleotide exchange factor 2; Rho/Rac guanine nucleotide exchange factor (GEF) 2; Rho/Rac guanine nucleotide exchange factor 2
Molecular Weight
Mass (kDA):
111.543 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 1q22 |
| Sequence: | 1; NC_000001.11 (155946839..155991262, complement) |
Subcellular Localizations
Cytoplasm, cytoskeleton. Cytoplasm. Cell junction, tight junction. Golgi apparatus. Cytoplasm, cytoskeleton, spindle. Cell projection, ruffle membrane. Cytoplasmic vesicle. Localizes to the tips of cortical microtubules of the mitotic spindle during cell division, and is further released upon microtubule depolymerization (PubMed:15827085). Recruited into membrane ruffles induced by S.flexneri at tight junctions of polarized epithelial cells (PubMed:19043560). Colocalized with NOD2 and RIPK2 in vesicles and with the cytoskeleton (PubMed:21887730).
Diseases
- Tissue Adhesions
- Malignant Neoplasms
- Neoplasms
- Cell Invasion
- Neoplasm Metastasis
- Inflammation
- Cell Transformation, Neoplastic
- Leukemia
- Malignant Neoplasm Of Breast
- Neoplasm Invasiveness
- Carcinoma
- Mammary Neoplasms
Interacting Proteins
- FOXO3
- RPP25L
- YWHAZ
Pathways
- Localization
- Cell Migration
- Cell Adhesion
- Cytokinesis
- Cell Motility
- Cell Proliferation
- Microtubule Depolymerization
- Cell Cycle
- Secretion
- Mitosis
- Pathogenesis
- Rna Interference
- Muscle Cell Proliferation
PTMs
- Phosphorylation
- Biotinylation
- Cleavage
Research Areas
- Cell Cycle and Replication
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/ARHGEF2
bosterbio.com/bosterbio-gene-info-cards/ARHGEF2
References
PMID: 9857026 by Ren Y., et al. Cloning and characterization of GEF-H1, a microtubule-associated guanine nucleotide exchange factor for Rac and Rho GTPases.
PMID: 11912491 by Krendel M., et al. Nucleotide exchange factor GEF-H1 mediates cross-talk between microtubules and the actin cytoskeleton.