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ARFGEF2 Antibodies
AND ARFGEF2 ELISA kits, ARFGEF2 Proteins
Many biological assays use antibodies to detect ARFGEF2, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with ARFGEF2 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop ARFGEF2 antibodies...
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ARFGEF2 Infographic by Boster Bio
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ARFGEF2 Overview
Facts about Brefeldin A-inhibited guanine nucleotide-exchange protein 2.
Brefeldin A-inhibited guanine nucleotide-exchange protein 2 (ARFGEF2)
Promotes guanine-nucleotide exchange on ARF1 and ARF3 and to a lower extent on ARF5 and ARF6.
Involved in the regulation of Golgi vesicular transport.Required for the integrity of the endosomal compartment. Involved in trafficking from the trans-Golgi network (TGN) to endosomes and is required for membrane association of the AP-1 complicated and GGA1.
Gene Information
| Human | |
|---|---|
| Gene Name: | ARFGEF2 |
| Uniprot: | Q9Y6D5 |
| Entrez: | 10564 |
Family
| Belongs to: |
|---|
| No superfamily |
Alternative Names
ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldinA-inhibited); ARFGEP2; BIG2brefeldin A-inhibited guanine nucleotide-exchange protein 2; Brefeldin A-inhibited GEP 2; dJ1164I10.1; FLJ23723; PVNH2
Molecular Weight
Mass (kDA):
202.038 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 20q13.13 |
| Sequence: | 20; NC_000020.11 (48921711..49036693) |
Tissue Specificity
Expressed in placenta, lung, heart, brain, kidney and pancreas.
Subcellular Localizations
Cytoplasm. Membrane. Golgi apparatus. Cytoplasm, perinuclear region. Golgi apparatus, trans-Golgi network. Endosome. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cell projection, dendrite. Cytoplasmic vesicle. Cell junction, synapse. Cytoplasm, cytoskeleton. Translocates from cytoplasm to membranes upon cAMP treatment. Localized in recycling endosomes.
Diseases
- Ectopic Tissue
- Microcephaly
- Periventricular Nodular Heterotopia
- Epilepsy
- Neuronal Migration Disorders
- Tissue Adhesions
- Dysplasia
- Nervousness
- Polymicrogyria
- Ehlers-danlos Syndrome
- Cortical Dysplasia
Interacting Proteins
- ARFGEF1
- MYCBP
- PDE3A
Pathways
- Transport
- Localization
- Membrane Tubulation
- Cell Adhesion
- Cell Activation
- Cerebral Cortex Development
- Immune Response
- Neurogenesis
- Protein Secretion
- System Development
- Cell Motility
- Golgi Organization
- Cognition
PTMs
- Ribosylation
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/ARFGEF2
bosterbio.com/bosterbio-gene-info-cards/ARFGEF2
References
PMID: 10212200 by Togawa A., et al. Purification and cloning of a brefeldin A-inhibited guanine nucleotide-exchange protein for ADP-ribosylation factors.
PMID: 10716990 by Yamaji R., et al. Identification and localization of two brefeldin A-inhibited guanine nucleotide-exchange proteins for ADP-ribosylation factors in a macromolecular complex.