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Ajuba Antibodies
AND Ajuba ELISA kits, Ajuba Proteins
Many biological assays use antibodies to detect Ajuba, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Ajuba in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Ajuba antibodies...
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Ajuba Overview
Facts about LIM domain-containing protein ajuba.
LIM domain-containing protein ajuba (Ajuba)
Adapter or scaffold protein which participates in the assembly of numerous protein complexes and is involved in a number of cellular processes such as cell fate determination, cytoskeletal organization, repression of gene transcription, mitosis, cell-cell adhesion, cell differentiation, proliferation and migration. Contributes to the strengthening or linking of epithelia cell- cell junctions in part by linking adhesive receptors to the actin cytoskeleton.
Plays an essential role in regulation of the kinase activity of AURKA for mitotic commitment. Also a component of the IL-1 signaling pathway regulating IL-1- induced NFKB1 activation by influencing the activity and assembly of the PRKCZ-SQSTM1-TRAF6 multiprotein signaling complex.
Gene Information
| Mouse | |
|---|---|
| Gene Name: | Ajuba |
| Uniprot: | Q91XC0 |
| Entrez: | 16475 |
Family
| Belongs to: |
|---|
| zyxin/ajuba family |
Alternative Names
Ajuba; JUB; jub, ajuba homolog (Xenopus laevis); MGC15563; protein ajuba
Molecular Weight
Mass (kDA):
57.92 kDA
Genomic Context
| Mouse | |
|---|---|
| Location: | 14|14 C2 |
| Sequence: | 14; |
Tissue Specificity
Expressed in skin, brain and genitourinary organs.
Diseases
- Tissue Adhesions
- Neoplasms
- Malignant Neoplasms
- Neoplasm Metastasis
- Mammary Neoplasms
- Refractory Anemia With Ringed Sideroblasts
- Carcinogenesis
- Crest Syndrome
- Malnutrition
- Teratoma
- Malignant Neoplasm Of Breast
- Tumor Progression
- Von Hippel-lindau Syndrome
Pathways
- Mitosis
- Cell Adhesion
- Cell Cycle
- Nuclear Export
- Localization
- Cell Division
- Cell-cell Adhesion
- Cell Proliferation
- Cell Migration
- Cell Fate Determination
- Chromosome Segregation
- Cytokinesis
- Regulation Of Cell Adhesion
PTMs
- Phosphorylation
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/Ajuba
bosterbio.com/bosterbio-gene-info-cards/Ajuba
References
PMID: 10330178 by Goyal R.K., et al. Ajuba, a novel LIM protein, interacts with Grb2, augments mitogen- activated protein kinase activity in fibroblasts, and promotes meiotic maturation of Xenopus oocytes in a Grb2- and Ras-dependent manner.
PMID: 11029037 by Kanungo J., et al. Ajuba, a cytosolic LIM protein, shuttles into the nucleus and affects embryonal cell proliferation and fate decisions.