Aicda Antibodies

AND Aicda ELISA kits, Aicda Proteins

Many biological assays use antibodies to detect Aicda, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Aicda in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Aicda antibodies...

We validate the specificity of these antibodies to Aicda by testing them on tissues known to express Aicda positively and negatively. Browse below to find the Aicda antibody that suites your experiment. We have 4 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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Aicda Infographic by Boster Bio

All Aicda Products

Product

Figures

Specificity

Applications

Price

Anti-AID AICDA Antibody

5 Q&As

Human, Mouse, Rat

IHC, WB

$399
Cat # A00267-1
100μl

Anti-AID AICDA Antibody

Human, Mouse

ELISA, IF, ICC, WB

$449
Cat # A00267
0.1 mg

Human AICDA Recombinant Protein

SDS-PAGE, Denatured

$250
Cat # PROTQ9GZX7
Starting from 20ug

AICDA (NM_020661) Human Over-expression Lysate

Human

$628
Cat # LS057379
100 µg

Aicda Overview

Facts about Single-stranded DNA cytosine deaminase.

Single-stranded DNA cytosine deaminase (Aicda)

Single-stranded DNA-specific cytidine deaminase. Involved in somatic hypermutation (SHM), gene conversion, and class-switch recombination (CSR) in B-lymphocytes by deaminating C to U during transcription of Ig-variable (V) and Ig-switch (S) region DNA.

Needed for several crucial steps of B-cell terminal differentiation required for efficient antibody responses. May also play a role in the epigenetic regulation of gene expression by participating in DNA demethylation.

Gene Information

Mouse
Gene Name:	Aicda
Uniprot:	Q9WVE0
Entrez:	11628

Family

Belongs to:

cytidine and deoxycytidylate deaminase family

Alternative Names

activation-induced cytidine deaminase; AICDA; AID; AIDCytidine aminohydrolase; Arp2; CDA2; HIGM2; HIGM2EC 3.5.4.5; integrated into Burkitt's lymphoma cell line Ramos

Molecular Weight

Mass (kDA):
24.031 kDA

Genomic Context


Mouse

Location:	6\|6 F1
Sequence:	6;

Diseases

Immunologic Deficiency Syndromes
Hyperimmunoglobulin M Syndrome
Infective Disorder
Lymphoma
B-cell Lymphomas
Asthma
Hypergammaglobulinemia
Cell Transformation, Neoplastic
Malignant Neoplasms
Neoplasms
Allergic Asthma
Hepatitis
Arthritis

Chromosomal Translocation
Acute Lymphocytic Leukemia
Primary Immune Deficiency Disorder
Autoimmune Reaction
Leukemia
Autoimmunity
Burkitt Lymphoma

Pathways

Dna Recombination
Cell Proliferation
Dna Repair
Immunoglobulin Production
Methylation
Pathogenesis
Secretion
Cell Activation
Cytidine Deamination
Plasma Cell Differentiation
Gene Conversion
Cell Differentiation
Dna Methylation

B Cell Proliferation
Isotype Switching
Germinal Center Formation
Immune Response
Dna Demethylation
Hypersensitivity
B Cell Activation

PTMs

Deamination
Methylation
Phosphorylation

Demethylation
Cleavage
Citrullination

Acetylation

Research Areas

DNA Repair
Epigenetics
Immunology
Lipid and Metabolism

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/Aicda

References

PMID: 10373455 by Muramatsu M., et al. Specific expression of activation-induced cytidine deaminase (AID), a novel member of the RNA-editing deaminase family in germinal center B cells.

PMID: 12692563 by Chaudhuri J., et al. Transcription-targeted DNA deamination by the AID antibody diversification enzyme.