Antizyme inhibitor 1 Antibodies

AND AZIN1 ELISA kits, Antizyme inhibitor 1 Proteins

Many biological assays use antibodies to detect Antizyme inhibitor 1, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Antizyme inhibitor 1 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Antizyme inhibitor 1 antibodies...

We validate the specificity of these antibodies to Antizyme inhibitor 1 by testing them on tissues known to express AZIN1 positively and negatively. Browse below to find the AZIN1 antibody that suites your experiment. We have 3 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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AZIN1 Infographic by Boster Bio

All AZIN1 Products

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Product

Figures

Specificity

Applications

Price

Anti-Antizyme inhibitor 1 (AZIN1) Mouse Monoclonal Antibody [Clone ID: OTI3C3]

Human, Mouse, Rat

IHC, WB

$523
Cat # M07957-1
100 µl

Anti-Antizyme inhibitor 1 (AZIN1) Mouse Monoclonal Antibody [Clone ID: OTI5C7]

Human, Mouse, Rat

$523
Cat # M07957
100 µl

Antizyme inhibitor 1 (AZIN1) (NM_015878) Human Over-expression Lysate

Human

$628
Cat # LS051582
100 µg

AZIN1 Overview

Facts about Antizyme inhibitor 1.

AZIN1 3D structure. Source: alphafold

Antizyme inhibitor 1 (AZIN1)

Antizyme inhibitor (AZI) protein that positively regulates ornithine decarboxylase (ODC) activity and polyamine uptake. AZI is an enzymatically inactive ODC homolog that counteracts the negative effect of ODC antizymes (AZs) OAZ1, OAZ2 and OAZ3 on ODC activity by competing with ODC for antizyme- binding (PubMed:17900240, PubMed:26305948).

Inhibits antizyme- dependent ODC degradation and releases ODC monomers in their inactive complex with antizymes, resulting in formation of the catalytically active ODC homodimer and restoring polyamine production (PubMed:17900240). .

Gene Information

Human
Gene Name:	AZIN1
Uniprot:	O14977
Entrez:	51582

Family

Belongs to:

Orn/Lys/Arg decarboxylase class-II family

Alternative Names

antizyme inhibitor 1; AZI; OAZIMGC691; OAZINEC 4.1.1.17; ODC1L; Ornithine decarboxylase antizyme inhibitorMGC3832

Molecular Weight

Mass (kDA):
49.535 kDA

Genomic Context


Human

Location:	8q22.3
Sequence:	8; NC_000008.11 (102826302..102864200, complement)

Tissue Specificity

Expressed in liver.

Subcellular Localizations

Nucleus.

Diseases

Neoplasms
Malignant Neoplasms
Hepatitis
Hepatitis C
Liver Cirrhosis
Hepatitis C, Chronic
Hypoxia
Fibrosis
Malignant Paraganglionic Neoplasm
Liver Diseases
Disease Of Adrenal Medulla
Neoplasm Metastasis

Leydig Cell Tumor
Mood Disorders
Hepatitis, Chronic
Tumor Progression
Glioma
Hepatitis B
Aneuploidy

Interacting Proteins

OAZ3

Pathways

Transport
Cell Proliferation
Localization
Cell Growth
Polyamine Homeostasis
Centrosome Duplication
Regulation Of Cell Cycle
Secretory Pathway
Polyamine Transport
Immune Response
Dna Methylation
Protein Secretion

Methylation
Translation
Cell Cycle
Embryonic Morphogenesis
Rna Interference
Excretion
Secretion

PTMs

Ubl conjugation

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/AZIN1

References

PMID: 9349715 by Koguchi K., et al. Cloning and sequencing of a human cDNA encoding ornithine decarboxylase antizyme inhibitor.

PMID: 17900240 by Kanerva K., et al. Human ornithine decarboxylase paralogue (ODCp) is an antizyme inhibitor but not an arginine decarboxylase.