Axin-1 Antibodies

AND AXIN1 ELISA kits, Axin-1 Proteins

Many biological assays use antibodies to detect Axin-1, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Axin-1 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Axin-1 antibodies...

We validate the specificity of these antibodies to Axin-1 by testing them on tissues known to express AXIN1 positively and negatively. Browse below to find the AXIN1 antibody that suites your experiment. We have 4 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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AXIN1 Infographic by Boster Bio

All AXIN1 Products

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Product

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Specificity

Applications

Price

Anti-Axin-1 AXIN1 Antibody

Human, Mouse, Rat

ELISA, IF, WB

$449
Cat # A00986
0.1 mg

Axin 1 (AXIN1) (NM_003502) Human Over-expression Lysate

Human

$960
Cat # LS008312
100 µg

Anti-AXIN1 Antibody Picoband®

Human, Mouse

ELISA, IF, ICC, WB

$370
Cat # A00986-2
100 µg/vial

Anti-AXIN1 Antibody Picoband®

Human

ELISA, WB

$370
Cat # A00986-3
100 μg/vial

AXIN1 Overview

Facts about Axin-1.

AXIN1 3D structure. Source: alphafold

Axin-1 (AXIN1)

Part of the beta-catenin destruction complex necessary for regulating CTNNB1 levels through phosphorylation and ubiquitination, and modulating Wnt-signaling (PubMed:12192039, PubMed:27098453). Controls dorsoventral patterning via two opposing effects; down-regulates CTNNB1 to inhibit the Wnt signaling pathway and ventralize embryos, but also dorsalizes embryos by sparking a Wnt-independent JNK signaling pathway (PubMed:12192039).

Likely to be a tumor suppressor. Enhances TGF-beta signaling by recruiting the RNF111 E3 ubiquitin ligase and promoting the degradation of inhibitory SMAD7 (PubMed:16601693).

Gene Information

Human
Gene Name:	AXIN1
Uniprot:	O15169
Entrez:	8312

Family

Belongs to:

No superfamily

Alternative Names

axin 1; Axin1; Axin-1; AXINaxis inhibitor 1; Axis inhibition protein 1; fused, mouse, homolog of; hAxin; MGC52315

Molecular Weight

Mass (kDA):
95.635 kDA

Genomic Context


Human

Location:	16p13.3
Sequence:	16; NC_000016.10 (287440..355226, complement)

Tissue Specificity

Ubiquitously expressed.

Subcellular Localizations

Cytoplasm. Nucleus. Membrane. Cell membrane. MACF1 is required for its translocation to cell membrane (By similarity). On UV irradiation, translocates to the nucleus and colocalizes with DAAX (PubMed:17210684).

Diseases

Malignant Neoplasms
Neoplasms
Carcinoma
Adenomatous Polyposis Coli
Polyposis
Carcinogenesis
Cell Transformation, Neoplastic
Liver Carcinoma
Liver Neoplasms
Colorectal Cancer
Colorectal Neoplasms
Malignant Tumor Of Colon
Malignant Paraganglionic Neoplasm

Medulloblastoma
Colonic Neoplasms
Malignant Neoplasm Of Breast
Adenocarcinoma
Hepatocarcinogenesis
Tumor Progression
Mammary Neoplasms

Pathways

Pathogenesis
Localization
Methylation
Cell Proliferation
Cell Cycle
Dna Methylation
Cell Growth
Cell Migration
Cell Differentiation
Oncogenesis
Rna Interference
Cell Activation
Ossification

Embryo Development
Mismatch Repair
Regeneration
Tissue Homeostasis
Fertilization
Cell Fate Determination
Inflammatory Response

PTMs

Phosphorylation
Methylation
Ubiquitination
Sumoylation

Dephosphorylation
Demethylation
Reduction
Cleavage

Ribosylation

Research Areas

Apoptosis
Wnt Signaling Pathway

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/AXIN1

References

PMID: 9230313 by Zeng L., et al. The mouse Fused locus encodes Axin, an inhibitor of the Wnt signaling pathway that regulates embryonic axis formation.

PMID: 9920888 by Hsu W., et al. Identification of a domain of Axin that binds to the serine/threonine protein phosphatase 2A and a self-binding domain.