This website uses cookies to ensure you get the best experience on our website.
- Table of Contents
Facts about Aurora kinase C.
Plays also a role in meiosis and more especially in spermatogenesis. Has redundant cellular functions with AURKB and can save an AURKB knockdown.
Human | |
---|---|
Gene Name: | AURKC |
Uniprot: | Q9UQB9 |
Entrez: | 6795 |
Belongs to: |
---|
protein kinase superfamily |
AIE2AIK3; ARK3Serine/threonine-protein kinase aurora-C; AurC; aurora kinase CAurora/IPL1/Eg2 protein 2; Aurora/IPL1-related kinase 3; aurora-C; Aurora-related kinase 3; EC 2.7.11; EC 2.7.11.1; serine/threonine kinase 13 (aurora/IPL1-like); serine/threonine-protein kinase 13; STK13ARK-3
Mass (kDA):
35.591 kDA
Human | |
---|---|
Location: | 19q13.43 |
Sequence: | 19; NC_000019.10 (57230317..57235550) |
Isoform 1 and isoform 2 are expressed in testis. Elevated expression levels were seen only in a subset of cancer cell lines such as Hep-G2, Huh-7 and HeLa. Expression is maximum at M phase.
Nucleus. Chromosome. Chromosome, centromere. Cytoplasm, cytoskeleton, spindle. Distributes in the condensed chromosomes during prophase to metaphase. After entering anaphase, there is a dissociation from separated chromosomes and a redistribution to midzone microtubules, and finally remains in the midbody during cytokinesis.
PMID: 9809744 by Tseng T.-C., et al. Protein kinase profile of sperm and eggs: cloning and characterization of two novel testis-specific protein kinases (AIE1, AIE2) related to yeast and fly chromosome segregation regulators.
PMID: 9799611 by Bernard M., et al. Cloning of STK13, a third human protein kinase related to Drosophila aurora and budding yeast Ipl1 that maps on chromosome 19q13.3-ter.