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Aurora kinase A Antibodies
AND AURKA ELISA kits, Aurora kinase A Proteins
Many biological assays use antibodies to detect Aurora kinase A, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Aurora kinase A in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Aurora kinase A antibodies...
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AURKA Infographic by Boster Bio
All AURKA Products
Product
Figures
Specificity
Applications
Price
Human, Mouse
Flow Cytometry, IF, ICC, WB
$370
Cat # M00246
100 μl
Cat # M00246
100 μl
Human, Mouse, Rat
ELISA, IHC, WB
$380
Cat # A00246T288-1
100ul
Cat # A00246T288-1
100ul
Human, Monkey, Rat
ELISA, Flow Cytometry, IF, WB
$380
Cat # M00246-5
100ul
Cat # M00246-5
100ul
Human
ELISA, Flow Cytometry, IF, IHC, ICC, WB
$370
Cat # A00246-3
100 μg/vial
Cat # A00246-3
100 μg/vial
Human
ELISA, Flow Cytometry, IHC, WB
$370
Cat # A00246-4
100 μg/vial
Cat # A00246-4
100 μg/vial
AURKA Overview
Facts about Aurora kinase A.
Aurora kinase A (AURKA)
Mitotic serine/threonine kinase that leads to the regulation of cell cycle progression. Associates with the centrosome and the spindle microtubules during mitosis and plays a critical role in various mitotic events such as the establishment of mitotic spindle, centrosome duplication, centrosome separation in addition to maturation, chromosomal alignment, spindle assembly checkpoint, and cytokinesis.
Required for initial activation of CDK1 in centrosomes. Phosphorylates numerous target proteins, such as ARHGEF2, BORA, BRCA1, CDC25B, DLGP5, HDAC6, KIF2A, LATS2, NDEL1, PARD3, PPP1R2, PLK1, RASSF1, TACC3, p53/TP53 and TPX2.
Gene Information
| Human | |
|---|---|
| Gene Name: | AURKA |
| Uniprot: | O14965 |
| Entrez: | 6790 |
Family
| Belongs to: |
|---|
| protein kinase superfamily |
Alternative Names
AIK; AIKAurA; ARK1; ARK-1; ARK1EC 2.7.11.1; AURA; AURKA; Aurora A; aurora kinase AhARK1; aurora/IPL1-like kinase; Aurora/IPL1-related kinase 1; Aurora-related kinase 1; Breast tumor-amplified kinase; breast-tumor-amplified kinase; BTAK; BTAKAURORA2; EC 2.7.11; IPL1-related kinase; serine/threonine kinase 6; serine/threonine protein kinase 15; Serine/threonine-protein kinase 15; serine/threonine-protein kinase 6; Serine/threonine-protein kinase aurora-A; STK15; STK15serine/threonine kinase 15; STK6; STK6MGC34538; STK7
Molecular Weight
Mass (kDA):
45.809 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 20q13.2 |
| Sequence: | 20; NC_000020.11 (56369389..56392337, complement) |
Tissue Specificity
Highly expressed in testis and weakly in skeletal muscle, thymus and spleen. Also highly expressed in colon, ovarian, prostate, neuroblastoma, breast and cervical cancer cell lines.
Subcellular Localizations
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, spindle pole. Cytoplasm, cytoskeleton, cilium basal body. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole. Cell projection, neuron projection. Detected at the neurite hillock in developing neurons (By similarity). Localizes at the centrosome in mitotic cells from early prophase until telophase, but also localizes to the spindle pole MTs from prophase to anaphase (PubMed:9606188, PubMed:17229885, PubMed:21225229). Colocalized with SIRT2 at centrosome (PubMed:22014574). Move
Diseases
- Malignant Neoplasms
- Neoplasms
- Malignant Neoplasm Of Breast
- Carcinoma
- Mammary Neoplasms
- Cell Transformation, Neoplastic
- Aneuploidy
- Colorectal Cancer
- Adenocarcinoma
- Carcinogenesis
- Colorectal Neoplasms
- Malignant Paraganglionic Neoplasm
- Malignant Neoplasm Of Ovary
Interacting Proteins
- AURKAIP1
- BIRC5
- EGFR
- HNRNPK
- IK
- IKBKB
- INCENP
- MYCN
- NPM1
- PLK1
Pathways
- Cell Cycle
- Mitosis
- Oocyte Maturation
- Chromosome Segregation
- Meiosis
- Cell Proliferation
- Cell Division
- Pathogenesis
- Cell Death
- Cell Growth
- Cytokinesis
- Spindle Assembly
- Metaphase
PTMs
- Phosphorylation
- Cleavage
- Methylation
Research Areas
- Breast Cancer
- Cancer
- Cell Cycle and Replication
- Checkpoint signaling
- Chromatin Research
- Core ESC-Like Genes
- MAP Kinase Signaling
- Mitotic Regulators
- Protein Kinase
- Signal Transduction
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/AURKA
bosterbio.com/bosterbio-gene-info-cards/AURKA
References
PMID: 9153231 by Kimura M., et al. Cell cycle-dependent expression and spindle pole localization of a novel human protein kinase, Aik, related to Aurora of Drosophila and yeast Ipl1.
PMID: 9514916 by Shindo M., et al. cDNA cloning, expression, subcellular localization, and chromosomal assignment of mammalian aurora homologues, aurora-related kinase (ARK) 1 and 2.