Ataxin-2 Antibodies

AND ATXN2 ELISA kits, Ataxin-2 Proteins

Many biological assays use antibodies to detect Ataxin-2, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Ataxin-2 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Ataxin-2 antibodies...

We validate the specificity of these antibodies to Ataxin-2 by testing them on tissues known to express ATXN2 positively and negatively. Browse below to find the ATXN2 antibody that suites your experiment. We have 3 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

Previous: CBLIF Next: ATXN7

ATXN2 Infographic by Boster Bio

All ATXN2 Products

Filter by Application:

Product

Figures

Specificity

Applications

Price

Anti-ATX2/ATXN2 Antibody Picoband®

9 Q&As

Human, Mouse, Rat

IHC, WB

$370
Cat # PB9483
100 μg/vial

Anti-ATX2/ATXN2 Antibody Picoband®

Human, Mouse, Rat

Flow Cytometry, IF, IHC, ICC, WB

$370
Cat # PA2098
100 μg/vial

Anti-SCA2/ATXN2 Antibody Picoband®

Human

ELISA, IHC, WB

$370
Cat # A01915
100 μg/vial

ATXN2 Overview

Facts about Ataxin-2.

ATXN2 3D structure. Source: alphafold

Ataxin-2 (ATXN2)

Involved in EGFR trafficking, acting as negative regulator of endocytic EGFR internalization at the plasma membrane. .

Gene Information

Human
Gene Name:	ATXN2
Uniprot:	Q99700
Entrez:	6311

Family

Belongs to:

ataxin-2 family

Alternative Names

ataxin 2; ataxin 2); ataxin-2; ATX2spinocerebellar ataxia 2 (olivopontocerebellar ataxia 2, autosomal dominant; SCA2FLJ46772; Spinocerebellar ataxia type 2 protein; TNRC13; trinucleotide repeat containing 13; Trinucleotide repeat-containing gene 13 protein

Molecular Weight

Mass (kDA):
140.283 kDA

Genomic Context


Human

Location:	12q24.12
Sequence:	12; NC_000012.12 (111452214..111599676, complement)

Tissue Specificity

Expressed in the brain, heart, liver, skeletal muscle, pancreas and placenta. Isoform 1 is predominant in the brain and spinal cord. Isoform 4 is more abundant in the cerebellum. In the brain, broadly expressed in the amygdala, caudate nucleus, corpus callosum, hippocampus, hypothalamus, substantia nigra, subthalamic nucleus and thalamus.

Subcellular Localizations

Cytoplasm.

Diseases

Ataxia
Ataxia, Spinocerebellar
Spinocerebellar Ataxia Type 2
Sclerosis
Primary Lateral Sclerosis
Amyotrophic Lateral Sclerosis
Trinucleotide Repeat Expansion
Neurodegenerative Disorders
Parkinson Disease
Secondary Parkinson Disease
Cerebellar Ataxia

Atrophy
Peripheral Neuropathy
Chronic Kidney Disease
Kidney Failure, Chronic
Kidney Diseases
Obesity

Interacting Proteins

ATXN1
DDX6
G3BP1
PABPC1
SH3GL2

SH3GL3
TARDBP

Pathways

Pathogenesis
Glomerular Filtration
Aging
Endocytosis
Transport
Dna Methylation
Dna Repair
Nuclear Export
Localization
Methylation
Translation

Conditioned Taste Aversion
Mrna Processing
Angiogenesis
Rna Processing
Secretion
Kidney Development

PTMs

Phosphorylation

Cleavage

Methylation

Research Areas

Cellular Markers
Hematopoietic Stem Cell Markers
Stem Cell Markers

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/ATXN2

References

PMID: 8896555 by Pulst S.-M., et al. Moderate expansion of a normally biallelic trinucleotide repeat in spinocerebellar ataxia type 2.

PMID: 8896556 by Sanpei K., et al. Identification of the spinocerebellar ataxia type 2 gene using a direct identification of repeat expansion and cloning technique, DIRECT.