ATP8B1 Antibodies

AND ATP8B1 ELISA kits, ATP8B1 Proteins

Many biological assays use antibodies to detect ATP8B1, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with ATP8B1 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop ATP8B1 antibodies...

We validate the specificity of these antibodies to ATP8B1 by testing them on tissues known to express ATP8B1 positively and negatively. Browse below to find the ATP8B1 antibody that suites your experiment. We have 0 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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ATP8B1 Infographic by Boster Bio

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ATP8B1 Overview

Facts about Phospholipid-transporting ATPase IC.

ATP8B1 3D structure. Source: alphafold

Phospholipid-transporting ATPase IC (ATP8B1)

Catalytic component of a P4-ATPase flippase complex which catalyzes the hydrolysis of ATP coupled to the transport of aminophospholipids in the outer to the inner leaflet of various membranes and ensures the maintenance of asymmetric distribution of phospholipids. Phospholipid translocation seems also to be implicated in vesicle formation and in uptake of lipid signaling molecules.

May play a role in asymmetric distribution of phospholipids in the canicular membrane. May have a role in transport of bile acids into the canaliculus, uptake of bile acids from intestinal contents to intestinal mucosa or both.

Gene Information

Human
Gene Name:	ATP8B1
Uniprot:	O43520
Entrez:	5205

Family

Belongs to:

cation transport ATPase (P-type) (TC 3.A.3) family

Alternative Names

ATPase class I type 8B member 1; ATPase, aminophospholipid transporter, class I, type 8B, member 1; ATPase, class I, type 8B, member 1; ATPICPFIC1; BRIC; EC 3.6.3; EC 3.6.3.1; Familial intrahepatic cholestasis type 1; FIC1phospholipid-transporting ATPase IC; PFICE1-E2 ATPase; probable phospholipid-transporting ATPase IC

Molecular Weight

Mass (kDA):
143.695 kDA

Genomic Context


Human

Location:	18q21.31
Sequence:	18; NC_000018.10 (57646426..57803822, complement)

Tissue Specificity

Found in most tissues except brain and skeletal muscle. Most abundant in pancreas and small intestine.

Subcellular Localizations

Cell membrane; Multi-pass membrane protein. Apical cell membrane. Cell projection, stereocilium. Endoplasmic reticulum. Golgi apparatus. Exit from the endoplasmic reticulum requires the presence of TMEM30A or TMEM30B (PubMed:20947505). Localizes to apical membranes in epithelial cells (PubMed:20512993).