ARPC1B Antibodies

AND ARPC1B ELISA kits, ARPC1B Proteins

Many biological assays use antibodies to detect ARPC1B, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with ARPC1B in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop ARPC1B antibodies...

We validate the specificity of these antibodies to ARPC1B by testing them on tissues known to express ARPC1B positively and negatively. Browse below to find the ARPC1B antibody that suites your experiment. We have 3 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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ARPC1B Infographic by Boster Bio

All ARPC1B Products

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Specificity

Applications

Price

Anti-ARP2/3 subunit 1B/ARPC1B Antibody Picoband®

1 Q&As

Human, Mouse, Rat

ELISA, Flow Cytometry, IHC, WB

$370
Cat # A07192-2
100 μg/vial

ARPC1B (NM_005720) Human Recombinant Protein

$1062
Cat # PROTO15143
20 µg

ARPC1B (NM_005720) Human Over-expression Lysate

Human

$628
Cat # LS010095
100 µg

ARPC1B Overview

Facts about Actin-related protein 2/3 complex subunit 1B.

ARPC1B 3D structure. Source: alphafold

Actin-related protein 2/3 complex subunit 1B (ARPC1B)

Part of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation- promoting factor (NPF) (PubMed:11741539, PubMed:9230079). The Arp2/3 complex mediates the formation of branched actin networks in the cytoplasm, providing the force for cell motility (PubMed:11741539, PubMed:9230079).

Besides its function in the cytoplasmic cytoskeleton, the Arp2/3 complex also promotes actin polymerization in the nucleus, thereby regulating gene transcription and repair of damaged DNA (PubMed:29925947). The Arp2/3 complex promotes homologous recombination (HR) repair in response to DNA damage by promoting nuclear actin polymerization, resulting in drive motility of double-strand breaks (DSBs) (PubMed:29925947).

Gene Information

Human
Gene Name:	ARPC1B
Uniprot:	O15143
Entrez:	10095

Family

Belongs to:

WD repeat ARPC1 family

Alternative Names

actin related protein 2/3 complex, subunit 1B (41 kD); actin related protein 2/3 complex, subunit 1B, 41kDa; actin-related protein 2/3 complex subunit 1B; ARC41p41-ARCp40-ARC; Arp2/3 complex 41 kDa subunit; ARP2/3 protein complex subunit p41

Molecular Weight

Mass (kDA):
40.95 kDA

Genomic Context


Human

Location:	7q22.1
Sequence:	7; NC_000007.14 (99374254..99394816)

Subcellular Localizations

Cytoplasm, cytoskeleton. Nucleus.

Diseases

Malignant Neoplasms
Stomach Neoplasms
Neoplasms
Malignant Paraganglionic Neoplasm
Malignant Neoplasm Of Stomach
Neoplasm Metastasis
Oncogene Activation Process
Melanoma
Malignant Neoplasm Of Breast
Bone Neoplasms
Malignant Neoplasm Of Lung
Carcinoma

Dysplasia
Osteosarcoma
Loss Of Chromosome 5q
Malignant Neoplasm Of Ovary
Epithelial Ovarian Cancer
Malignant Neoplasm Of Pancreas
Ovarian Neoplasm

Interacting Proteins

ARPC3

Pathways

Methylation
Cell Cycle
Senescence
Cell Migration
Cell Motility
Locomotion
Cellular Senescence
Regulation Of Mitosis
Mitosis

Dna Methylation
Localization
Actin Nucleation

PTMs

Methylation

Phosphorylation

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/ARPC1B

References

PMID: 9230079 by Welch M.D., et al. The human Arp2/3 complex is composed of evolutionarily conserved subunits and is localized to cellular regions of dynamic actin filament assembly.

PMID: 11741539 by Gournier H., et al. Reconstitution of human Arp2/3 complex reveals critical roles of individual subunits in complex structure and activity.