ARHGAP32 Antibodies

AND ARHGAP32 ELISA kits, ARHGAP32 Proteins

Many biological assays use antibodies to detect ARHGAP32, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with ARHGAP32 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop ARHGAP32 antibodies...

We validate the specificity of these antibodies to ARHGAP32 by testing them on tissues known to express ARHGAP32 positively and negatively. Browse below to find the ARHGAP32 antibody that suites your experiment. We have 0 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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ARHGAP32 Infographic by Boster Bio

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ARHGAP32 Overview

Facts about Rho GTPase-activating protein 32.

ARHGAP32 3D structure. Source: alphafold

Rho GTPase-activating protein 32 (ARHGAP32)

GTPase-activating protein (GAP) promoting GTP hydrolysis on RHOA, CDC42 and RAC1 small GTPases. May be involved in the differentiation of neuronal cells during the formation of neurite extensions.

Involved in NMDA receptor activity-dependent actin reorganization in dendritic spines. May mediate cross-talks involving Ras- and Rho-regulated signaling pathways in cell growth regulation.

Gene Information

Human
Gene Name:	ARHGAP32
Uniprot:	A7KAX9
Entrez:	9743

Family

Belongs to:

PX domain-containing GAP family

Alternative Names

brain-specific Rho GTP-ase-activating protein; Brain-specific Rho GTPase-activating protein; GAB-associated CDC42; GAB-associated Cdc42/Rac GTPase-activating protein; GC-GAPGTPase regulator interacting with TrkA; GRITp200RhoGAP; KIAA0712p250GAP; MGC1892; rac GTPase activating protein; Rho GTPase activating protein 32; rho GTPase-activating protein 32; Rho/Cdc42/Rac GTPase-activating protein RICS; RhoGAP involved in the beta-catenin-N-cadherin and NMDA receptor signaling; RhoGAP involved in the -catenin-N-cadherin and NMDA receptor signaling; Rho-type GTPase-activating protein 32; RICSPX-RICS

Molecular Weight

Mass (kDA):
230.529 kDA

Genomic Context


Human

Location:	11q24.3
Sequence:	11; NC_000011.10 (128965060..129279518, complement)

Tissue Specificity

Isoform 1 and isoform 2 are highly expressed in brain and testis. Isoform 1 is also expressed in other tissues such as lung, liver and spleen.

Subcellular Localizations

Cell junction, synapse, postsynaptic density. Cell projection, dendritic spine. Cytoplasm, cell cortex. Endosome membrane. Golgi apparatus membrane. Endoplasmic reticulum membrane. Membrane. Association to membrane via PX domain (PubMed:17663722). Associated with cortical actin in undifferentiated neuroblastoma cells, but localized to dendritic spine and postsynaptic density after differentiation (By similarity). Colocalizes with EGFR at the cell membrane upon EGF treatment (PubMed:12446789). Colocalizes with GAB2 at the cell membrane (PubMed:12819203).

Interacting Proteins

ABI2
AES
DZIP3
FYN
LZTS2

MDFI
NCK2

PTMs

Methylation

Phosphoprotein

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/ARHGAP32

References

PMID: 12446789 by Nakamura T., et al. Grit, a GTPase-activating protein for the Rho family, regulates neurite extension through association with the TrkA receptor and N-Shc and CrkL/Crk adapter molecules.

PMID: 12531901 by Okabe T., et al. RICS, a novel GTPase-activating protein for Cdc42 and Rac1, is involved in the beta-catenin-N-cadherin and N-methyl-D-aspartate receptor signaling.